Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 10567..11120 | Replicon | plasmid pCFSAN058605_02 |
| Accession | NZ_CP077695 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058605 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A3R0G118 |
| Locus tag | DAY14_RS25700 | Protein ID | WP_058645035.1 |
| Coordinates | 10806..11120 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A6P1V7Y5 |
| Locus tag | DAY14_RS25695 | Protein ID | WP_025861853.1 |
| Coordinates | 10567..10803 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAY14_RS25660 (DAY14_025665) | 5650..6360 | - | 711 | WP_079904513.1 | lytic transglycosylase domain-containing protein | - |
| DAY14_RS25665 (DAY14_025670) | 6478..6696 | - | 219 | WP_004178172.1 | hypothetical protein | - |
| DAY14_RS25670 (DAY14_025675) | 6701..6916 | - | 216 | WP_004178170.1 | hypothetical protein | - |
| DAY14_RS25675 (DAY14_025680) | 6988..7443 | - | 456 | WP_058645037.1 | transcription termination/antitermination NusG family protein | - |
| DAY14_RS25680 (DAY14_025685) | 7693..8052 | + | 360 | WP_057517074.1 | helix-turn-helix transcriptional regulator | - |
| DAY14_RS25685 (DAY14_025690) | 8513..9220 | + | 708 | WP_254891021.1 | RepA protein | - |
| DAY14_RS25690 (DAY14_025695) | 10027..10458 | + | 432 | WP_058645036.1 | hypothetical protein | - |
| DAY14_RS25695 (DAY14_025700) | 10567..10803 | + | 237 | WP_025861853.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| DAY14_RS25700 (DAY14_025705) | 10806..11120 | + | 315 | WP_058645035.1 | CcdB family protein | Toxin |
| DAY14_RS25705 (DAY14_025710) | 11161..11325 | + | 165 | WP_165801018.1 | hypothetical protein | - |
| DAY14_RS26105 | 11341..11454 | + | 114 | Protein_17 | XRE family transcriptional regulator | - |
| DAY14_RS26110 | 11873..12228 | + | 356 | Protein_18 | SprT-like domain-containing protein | - |
| DAY14_RS25710 (DAY14_025715) | 12693..14444 | + | 1752 | WP_058645033.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
| DAY14_RS25715 (DAY14_025720) | 14447..14704 | + | 258 | WP_070794402.1 | bacteriocin immunity protein | - |
| DAY14_RS25720 (DAY14_025725) | 14788..14934 | + | 147 | WP_057394955.1 | colicin release lysis protein | - |
| DAY14_RS25725 (DAY14_025730) | 15049..15489 | + | 441 | Protein_22 | AAA family ATPase | - |
| DAY14_RS25730 (DAY14_025735) | 15569..15781 | + | 213 | Protein_23 | sprT domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..26031 | 26031 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11542.39 Da Isoelectric Point: 5.8036
>T207523 WP_058645035.1 NZ_CP077695:10806-11120 [Salmonella enterica subsp. enterica]
MQFTVYSNTGKSTVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AAFCDASPYRTEVKAAIDFLLDGI
MQFTVYSNTGKSTVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AAFCDASPYRTEVKAAIDFLLDGI
Download Length: 315 bp
>T207523 NZ_CP103329:760948-761244 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8907.84 Da Isoelectric Point: 4.8040
>AT207523 WP_025861853.1 NZ_CP077695:10567-10803 [Salmonella enterica subsp. enterica]
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF
Download Length: 237 bp
>AT207523 NZ_CP103329:761246-761641 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3R0G118 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V7Y5 |