Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 117688..118331 | Replicon | plasmid pCFSAN058605_01 |
| Accession | NZ_CP077694 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058605 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A632GNP3 |
| Locus tag | DAY14_RS25525 | Protein ID | WP_001644958.1 |
| Coordinates | 117688..118104 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A5Z7X8E3 |
| Locus tag | DAY14_RS25530 | Protein ID | WP_001644959.1 |
| Coordinates | 118101..118331 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAY14_RS25505 (DAY14_025510) | 113414..114388 | - | 975 | WP_001644948.1 | ParB family protein | - |
| DAY14_RS25510 (DAY14_025515) | 114388..115593 | - | 1206 | WP_001644949.1 | AAA family ATPase | - |
| DAY14_RS25515 (DAY14_025520) | 115841..116461 | + | 621 | WP_001644950.1 | recombinase family protein | - |
| DAY14_RS25520 (DAY14_025525) | 116597..117292 | + | 696 | WP_024153690.1 | IS6 family transposase | - |
| DAY14_RS26085 | 117346..117546 | + | 201 | Protein_125 | Lrp/AsnC family transcriptional regulator | - |
| DAY14_RS25525 (DAY14_025530) | 117688..118104 | - | 417 | WP_001644958.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| DAY14_RS25530 (DAY14_025535) | 118101..118331 | - | 231 | WP_001644959.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| DAY14_RS25535 (DAY14_025540) | 118764..119027 | + | 264 | WP_024153651.1 | hypothetical protein | - |
| DAY14_RS25540 (DAY14_025545) | 119080..119469 | - | 390 | Protein_129 | IS3 family transposase | - |
| DAY14_RS25545 (DAY14_025550) | 119616..122405 | - | 2790 | WP_070801099.1 | autotransporter outer membrane beta-barrel domain-containing protein | - |
| DAY14_RS25550 (DAY14_025555) | 122726..122965 | + | 240 | Protein_131 | RNA 2'-phosphotransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iroN / iroN | 1..137153 | 137153 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15078.48 Da Isoelectric Point: 9.1880
>T207522 WP_001644958.1 NZ_CP077694:c118104-117688 [Salmonella enterica subsp. enterica]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK
Download Length: 417 bp
>T207522 NZ_CP103329:c647986-647522 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8706.80 Da Isoelectric Point: 4.4692
>AT207522 WP_001644959.1 NZ_CP077694:c118331-118101 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL
Download Length: 231 bp
>AT207522 NZ_CP103329:c648321-647986 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A632GNP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z7X8E3 |