Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2751441..2752087 Replicon chromosome
Accession NC_004088
Organism Yersinia pestis KIM10+

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag Y_RS12875 Protein ID WP_002214976.1
Coordinates 2751441..2751623 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag Y_RS12880 Protein ID WP_002211129.1
Coordinates 2751668..2752087 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y_RS12840 2746827..2747297 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
Y_RS12845 2747303..2748304 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
Y_RS12850 2748301..2748717 + 417 WP_002211134.1 flagellar motor switch protein FliN -
Y_RS12855 2748717..2749253 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
Y_RS12860 2749334..2750074 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
Y_RS12865 2750180..2750449 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
Y_RS12870 2750452..2751234 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
Y_RS12875 2751441..2751623 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
Y_RS12880 2751668..2752087 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Y_RS12885 2752345..2753304 - 960 WP_002223882.1 sugar kinase -
Y_RS12890 2753353..2754375 - 1023 WP_002214974.1 ABC transporter permease -
Y_RS12895 2754378..2755955 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
Y_RS12900 2756021..2757016 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T20752 WP_002214976.1 NC_004088:2751441-2751623 [Yersinia pestis KIM10+]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T20752 NC_004088:2751441-2751623 [Yersinia pestis KIM10+]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT20752 WP_002211129.1 NC_004088:2751668-2752087 [Yersinia pestis KIM10+]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT20752 NC_004088:2751668-2752087 [Yersinia pestis KIM10+]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References