Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4393272..4393788 Replicon chromosome
Accession NZ_CP077693
Organism Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAY14_RS21625 Protein ID WP_000220578.1
Coordinates 4393272..4393556 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DAY14_RS21630 Protein ID WP_000212724.1
Coordinates 4393546..4393788 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY14_RS21610 (4388388) 4388388..4390040 + 1653 WP_021294549.1 alpha,alpha-phosphotrehalase -
DAY14_RS21615 (4390449) 4390449..4392587 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DAY14_RS21620 (4392804) 4392804..4393268 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAY14_RS21625 (4393272) 4393272..4393556 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAY14_RS21630 (4393546) 4393546..4393788 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAY14_RS21635 (4393866) 4393866..4395779 - 1914 WP_001212145.1 BglG family transcription antiterminator -
DAY14_RS21640 (4395796) 4395796..4396536 - 741 WP_000779259.1 KDGP aldolase family protein -
DAY14_RS21645 (4396533) 4396533..4397651 - 1119 WP_023197793.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAY14_RS21650 (4397635) 4397635..4398768 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207519 WP_000220578.1 NZ_CP077693:c4393556-4393272 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207519 NZ_CP103322:c3862-3596 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207519 WP_000212724.1 NZ_CP077693:c4393788-4393546 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207519 NZ_CP103322:c4070-3846 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References