Detailed information of TA system TA207514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3664966..3665586
• Replicon: chromosome
• Accession: NZ_CP077693
• Organism: Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: DAY14_RS18160
• Protein ID: WP_001280991.1
• Coordinates: 3665368..3665586 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: DAY14_RS18155
• Protein ID: WP_000344807.1
• Coordinates: 3664966..3665340 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAY14_RS18145 (3660105)	3660105..3661298	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DAY14_RS18150 (3661321)	3661321..3664470	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
DAY14_RS18155 (3664966)	3664966..3665340	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
DAY14_RS18160 (3665368)	3665368..3665586	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
DAY14_RS18165 (3665765)	3665765..3666316	+	552	WP_001278792.1	maltose O-acetyltransferase	-
DAY14_RS18170 (3666433)	3666433..3666903	+	471	WP_000136181.1	YlaC family protein	-
DAY14_RS18175 (3666959)	3666959..3667099	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
DAY14_RS18180 (3667105)	3667105..3667365	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
DAY14_RS18185 (3667590)	3667590..3669140	+	1551	WP_000213140.1	EAL domain-containing protein	-
DAY14_RS18195 (3669371)	3669371..3669760	+	390	WP_000961285.1	MGMT family protein	-
DAY14_RS18200 (3669793)	3669793..3670362	-	570	WP_020437370.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T207514 WP_001280991.1 NZ_CP077693:3665368-3665586 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T207514 NZ_CP103316:63789-64259 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT207514 WP_000344807.1 NZ_CP077693:3664966-3665340 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT207514 NZ_CP103316:63349-63792 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0