Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 948467..949127 Replicon chromosome
Accession NZ_CP077693
Organism Salmonella enterica subsp. enterica strain CFSAN058605

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DAY14_RS04565 Protein ID WP_000244756.1
Coordinates 948714..949127 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAY14_RS04560 Protein ID WP_000351186.1
Coordinates 948467..948733 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY14_RS04540 (944395) 944395..945828 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
DAY14_RS04545 (945987) 945987..946298 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DAY14_RS04550 (946462) 946462..947121 + 660 WP_000250289.1 hemolysin III family protein -
DAY14_RS04555 (947237) 947237..948217 - 981 WP_000874175.1 tRNA-modifying protein YgfZ -
DAY14_RS04560 (948467) 948467..948733 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAY14_RS04565 (948714) 948714..949127 + 414 WP_000244756.1 protein YgfX Toxin
DAY14_RS04570 (949180) 949180..949701 - 522 WP_001055885.1 flavodoxin FldB -
DAY14_RS04575 (949814) 949814..950710 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DAY14_RS04580 (950734) 950734..951447 + 714 WP_000745622.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAY14_RS04585 (951453) 951453..953186 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T207502 WP_000244756.1 NZ_CP077693:948714-949127 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207502 NZ_CP103315:330518-330886 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207502 WP_000351186.1 NZ_CP077693:948467-948733 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207502 NZ_CP103315:330300-330521 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References