Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 117693..118336 Replicon plasmid pCFSAN058620
Accession NZ_CP077692
Organism Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)


Gene name vagD Uniprot ID A0A632GNP3
Locus tag DAX98_RS25395 Protein ID WP_001644958.1
Coordinates 117693..118109 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag DAX98_RS25400 Protein ID WP_001644959.1
Coordinates 118106..118336 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX98_RS25375 (DAX98_025375) 113419..114393 - 975 WP_001644948.1 ParB family protein -
DAX98_RS25380 (DAX98_025380) 114393..115598 - 1206 WP_001644949.1 AAA family ATPase -
DAX98_RS25385 (DAX98_025385) 115846..116466 + 621 WP_001644950.1 recombinase family protein -
DAX98_RS25390 (DAX98_025390) 116602..117297 + 696 WP_024153690.1 IS6 family transposase -
DAX98_RS25765 117351..117551 + 201 Protein_125 Lrp/AsnC family transcriptional regulator -
DAX98_RS25395 (DAX98_025395) 117693..118109 - 417 WP_001644958.1 type II toxin-antitoxin system VapC family toxin Toxin
DAX98_RS25400 (DAX98_025400) 118106..118336 - 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DAX98_RS25405 (DAX98_025405) 118769..119032 + 264 WP_024153651.1 hypothetical protein -
DAX98_RS25410 (DAX98_025410) 119085..119474 - 390 Protein_129 IS3 family transposase -
DAX98_RS25415 (DAX98_025415) 119621..122431 - 2811 WP_070812003.1 autotransporter outer membrane beta-barrel domain-containing protein -
DAX98_RS25420 (DAX98_025420) 122752..122991 + 240 Protein_131 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroN / pilW 1..137180 137180
- flank IS/Tn - - 116602..117297 695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15078.48 Da        Isoelectric Point: 9.1880

>T207500 WP_001644958.1 NZ_CP077692:c118109-117693 [Salmonella enterica subsp. enterica]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

>T207500 NZ_CP103308:2968299-2968547 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAACACACCGAAAGGGAACTC
ATCGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT207500 WP_001644959.1 NZ_CP077692:c118336-118106 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp

>AT207500 NZ_CP103308:2968544-2968798 [Rhodococcus pyridinivorans]
GTGAACATCACCTTCACCGACGAAGCGTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAACAGCTCGAGCGTGT
CAACGAGCTGGTCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A632GNP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References