Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4340104..4340620 Replicon chromosome
Accession NZ_CP077691
Organism Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAX98_RS21285 Protein ID WP_000220578.1
Coordinates 4340104..4340388 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DAX98_RS21290 Protein ID WP_000212724.1
Coordinates 4340378..4340620 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX98_RS21270 (4335220) 4335220..4336872 + 1653 WP_021294549.1 alpha,alpha-phosphotrehalase -
DAX98_RS21275 (4337281) 4337281..4339419 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DAX98_RS21280 (4339636) 4339636..4340100 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX98_RS21285 (4340104) 4340104..4340388 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX98_RS21290 (4340378) 4340378..4340620 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX98_RS21295 (4340698) 4340698..4342611 - 1914 WP_001212145.1 BglG family transcription antiterminator -
DAX98_RS21300 (4342628) 4342628..4343368 - 741 WP_000779259.1 KDGP aldolase family protein -
DAX98_RS21305 (4343365) 4343365..4344483 - 1119 WP_023197793.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX98_RS21310 (4344467) 4344467..4345600 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207497 WP_000220578.1 NZ_CP077691:c4340388-4340104 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207497 NZ_CP103307:c5238281-5238003 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207497 WP_000212724.1 NZ_CP077691:c4340620-4340378 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207497 NZ_CP103307:c5237991-5237686 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References