Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3647998..3648618 Replicon chromosome
Accession NZ_CP077691
Organism Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAX98_RS18055 Protein ID WP_001280991.1
Coordinates 3648400..3648618 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAX98_RS18050 Protein ID WP_000344807.1
Coordinates 3647998..3648372 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX98_RS18040 (3643138) 3643138..3644331 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAX98_RS18045 (3644354) 3644354..3647502 + 3149 Protein_3553 efflux RND transporter permease AcrB -
DAX98_RS18050 (3647998) 3647998..3648372 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAX98_RS18055 (3648400) 3648400..3648618 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAX98_RS18060 (3648797) 3648797..3649348 + 552 WP_001278792.1 maltose O-acetyltransferase -
DAX98_RS18065 (3649465) 3649465..3649935 + 471 WP_000136181.1 YlaC family protein -
DAX98_RS18070 (3649991) 3649991..3650131 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DAX98_RS18075 (3650137) 3650137..3650397 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DAX98_RS18080 (3650622) 3650622..3652172 + 1551 WP_000213140.1 EAL domain-containing protein -
DAX98_RS18090 (3652403) 3652403..3652792 + 390 WP_000961285.1 MGMT family protein -
DAX98_RS18095 (3652825) 3652825..3653394 - 570 WP_020437370.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207492 WP_001280991.1 NZ_CP077691:3648400-3648618 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207492 NZ_CP103307:c143848-143567 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207492 WP_000344807.1 NZ_CP077691:3647998-3648372 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207492 NZ_CP103307:c144072-143845 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References