Detailed information of TA system TA207491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2289584..2290229
• Replicon: chromosome
• Accession: NZ_CP077691
• Organism: Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Z7XAV3
• Locus tag: DAX98_RS11265
• Protein ID: WP_070800844.1
• Coordinates: 2290047..2290229 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A5Z7XCZ9
• Locus tag: DAX98_RS11260
• Protein ID: WP_058645148.1
• Coordinates: 2289584..2290018 (-)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX98_RS11245 (2284685)	2284685..2285428	+	744	WP_108450264.1	C40 family peptidase	-
DAX98_RS11250 (2285326)	2285326..2286033	+	708	WP_031604554.1	tail assembly protein	-
DAX98_RS11255 (2286104)	2286104..2289517	+	3414	WP_259406987.1	host specificity protein J	-
DAX98_RS11260 (2289584)	2289584..2290018	-	435	WP_058645148.1	transcriptional regulator	Antitoxin
DAX98_RS11265 (2290047)	2290047..2290229	-	183	WP_070800844.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAX98_RS11270 (2290318)	2290318..2291199	+	882	WP_070794208.1	prophage tail fiber N-terminal domain-containing protein	-
DAX98_RS11275 (2291210)	2291210..2291803	+	594	WP_065314116.1	DUF4376 domain-containing protein	-
DAX98_RS11280 (2291911)	2291911..2292267	+	357	WP_070811990.1	DUF1353 domain-containing protein	-
DAX98_RS25630 (2292268)	2292268..2292573	-	306	WP_239909358.1	hypothetical protein	-
DAX98_RS11290 (2292570)	2292570..2292977	-	408	WP_024154330.1	hypothetical protein	-
DAX98_RS11295 (2293446)	2293446..2293721	-	276	WP_070811989.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2246955..2293721	46766

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6892.08 Da
• Isoelectric Point: 10.4804

>T207491 WP_070800844.1 NZ_CP077691:c2290229-2290047 [Salmonella enterica subsp. enterica]
MKYNEFRRWLIQQGAKFINAPDGGSHQRVILNGKESVFPCHGAKEMPEPLRKKILKDLGL

Nucleotide

• Length: 183 bp

>T207491 NZ_CP103300:c5989506-5989000 [Endozoicomonas euniceicola]
GTGGGAGTAATCAGGGCACCGGAATTACTGACAAAAGATCACAATACAGACGATTTTGATTGTGGCCATGATGTACTGAC
GGAATGGTTGAAAAAAACAGCTCTGAAAAATCAATCTGCCAATGCCAGCCGTACCTTTGTTGTGTGCAAAGGCGATAGGG
TTGTTGGTTACTACGCACTGTCCAGCGGCAGTATTGAACGAATGCAAACACCAAAATCCCTTGCCCGGAATATGCCAGAC
CCGATTCCAGTGACGGTGCTGGGGCGACTGGCCATTGATCAAGAGCATCAGGGAATGCGTATTGGCTCGGGTTTGTTGAA
AGATGCCATGATGCGAACACTGGTTGTATCCCAGCACATCGGTGTCAAAGCCATGTTGGTTCATGCTGTTTCCGAAGAAG
CCCGGCAATTCTACCTTCAGTACGGGTTTAAGGAATCTCCATTTAACCCCATGACACTGATGCTTCCGGTTAAACATATT
GTGGGCTTGTTTCCTGATCAGGGGTAA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15777.18 Da
• Isoelectric Point: 4.5833

>AT207491 WP_058645148.1 NZ_CP077691:c2290018-2289584 [Salmonella enterica subsp. enterica]
MFNYAVKPEYDPATESWVVTCRDLPLFNSVSFSIDDALLEAVDGAIVALSIEIDARRPVPIASQPEEGEYVIHLPVLVVM
KAALHNAMISTGTRKSDLARTMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVDNVAV

Nucleotide

• Length: 435 bp

>AT207491 NZ_CP103300:c5989760-5989497 [Endozoicomonas euniceicola]
ATGGCTAAAACAGTTCCCATCAATATGCGGGTTGAACCCGTACAGCAAGCTTTGCTGACCATGGCAGCGGCTGTGCTGAA
TAAGGATAGAACCGCTTTTATTCTTGATGTTGCCTGTCGGGAAGCGATGAATGTATTGCTTGATCAACGAGTATTTACTC
TGGATGAGGCTCAGACCAAAGCCTTTGAAGAGGCTCTCGAAGCACCTGTTCCTGAACAGAGTAAACTCAGTAAACTATTG
GCAGAGGCTGCACCGTGGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A5Z7XAV3

Antitoxin

• AlphaFold DB: A0A5Z7XCZ9