Detailed information of TA system TA207490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2263486..2264124
• Replicon: chromosome
• Accession: NZ_CP077691
• Organism: Salmonella enterica subsp. enterica strain CFSAN058620

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Z7XAU3
• Locus tag: DAX98_RS11115
• Protein ID: WP_072209095.1
• Coordinates: 2263942..2264124 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A5U4F813
• Locus tag: DAX98_RS11110
• Protein ID: WP_070811986.1
• Coordinates: 2263486..2263899 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX98_RS11085 (2258863)	2258863..2259090	+	228	WP_058645057.1	hypothetical protein	-
DAX98_RS11090 (2259169)	2259169..2261118	+	1950	WP_070809061.1	replication endonuclease	-
DAX98_RS11095 (2261263)	2261263..2261544	+	282	WP_108451050.1	hypothetical protein	-
DAX98_RS11100 (2261567)	2261567..2262703	+	1137	WP_143191461.1	DUF968 domain-containing protein	-
DAX98_RS11105 (2262700)	2262700..2263353	+	654	WP_070811985.1	bacteriophage antitermination protein Q	-
DAX98_RS11110 (2263486)	2263486..2263899	-	414	WP_070811986.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DAX98_RS11115 (2263942)	2263942..2264124	-	183	WP_072209095.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAX98_RS11120 (2264510)	2264510..2265022	+	513	WP_000259586.1	DUF1440 domain-containing protein	-
DAX98_RS11125 (2265708)	2265708..2266064	+	357	WP_058645064.1	hypothetical protein	-
DAX98_RS11130 (2266092)	2266092..2266277	-	186	WP_070809064.1	hypothetical protein	-
DAX98_RS11135 (2266579)	2266579..2266797	+	219	WP_058645066.1	phage holin	-
DAX98_RS11140 (2266775)	2266775..2267314	+	540	WP_070809065.1	lysozyme	-
DAX98_RS11145 (2267415)	2267415..2267879	+	465	WP_070809066.1	lysis protein	-
DAX98_RS11150 (2267911)	2267911..2268201	-	291	WP_070809067.1	Bor family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2246955..2293721	46766

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.15 Da
• Isoelectric Point: 10.8877

>T207490 WP_072209095.1 NZ_CP077691:c2264124-2263942 [Salmonella enterica subsp. enterica]
MKSSELIKLLESKGWTLERINGSHHHFSHPDFPVIITVPHPRKDIKPGTLNQILKKAKLK

Nucleotide

• Length: 183 bp

>T207490 NZ_CP103300:5632867-5633187 [Endozoicomonas euniceicola]
ATGGAATTTGTAGAAACCAGCGTATTTACCAAAATTATTACCCAGCTCATGTCTGATGATGATTATCGAGTCATGCAGGA
GACCATGATCGCCCAGCCTGACATTGGTAGCGTTATCAAAGGTACTGGGGGTTTACGGAAGTTTCGCTGGAAGCTGGGTA
GCTCCGGCAAACGGGGAGGCGTTCGCACCATCTATTACTGGCAGGTCAGTGAAGATACCTTCTACATGTTGTACGCCTAT
ACCAAAAACCGGCAAATAGACTTAACCAGTGCCGAGAAAAAAGTACTGTCAGAACTAGCGAGGGAGTTGTGCAATGAGTG
A

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15281.02 Da
• Isoelectric Point: 4.5174

>AT207490 WP_070811986.1 NZ_CP077691:c2263899-2263486 [Salmonella enterica subsp. enterica]
MLYPAFIEVDKDGSASGWFPDVPGCIFAGSTIEETYADARSAICAHFEVLCDKGFDIPSPRSIEQHVTAEPDDYSNGRWL
YVDVNMDQFDGRAERINVTLPHRLLDRIDATVKQHPDYGSRSAFLAAAARNELQKSL

Nucleotide

• Length: 414 bp

>AT207490 NZ_CP103300:5633180-5633476 [Endozoicomonas euniceicola]
ATGAGTGACCATGAATTTAACTTTGATGAATTAGTGGAGAGCGTAAGGGAAGCAATCGACATTAACAAAGGCATTAAGAA
GCCTTCACGGACATTCCAGTATGAAGAGATTGATGTAGCCAGTATCAGAAAAGCAACGCACCTCTCTCAGGAGAAGTTTG
CTGCACTCATTGGGGTGAGCATTAAGACAGTTCAGAGTTGGGAGCAGAAGGTGAGAAAACCGCTTGGGCCAGCCAGATCA
CTACTGATTATGTTTCGCAATAACCCAGTCCAGGCAATGAACTTACTTCACCAGTAA

Structures

Toxin

• AlphaFold DB: A0A5Z7XAU3

Antitoxin

• AlphaFold DB: A0A5U4F813