Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1109171..1109985 | Replicon | chromosome |
| Accession | NZ_CP077691 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058620 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | DAX98_RS05310 | Protein ID | WP_000971655.1 |
| Coordinates | 1109171..1109698 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | DAX98_RS05315 | Protein ID | WP_000855694.1 |
| Coordinates | 1109695..1109985 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX98_RS05280 (1105471) | 1105471..1105868 | + | 398 | Protein_1038 | cytoplasmic protein | - |
| DAX98_RS05285 (1106059) | 1106059..1106298 | + | 240 | Protein_1039 | hypothetical protein | - |
| DAX98_RS05290 (1106455) | 1106455..1107123 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| DAX98_RS05295 (1107150) | 1107150..1107644 | + | 495 | WP_000424942.1 | hypothetical protein | - |
| DAX98_RS05300 (1107889) | 1107889..1108545 | - | 657 | WP_020437799.1 | protein-serine/threonine phosphatase | - |
| DAX98_RS05305 (1108883) | 1108883..1109098 | + | 216 | Protein_1043 | IS5/IS1182 family transposase | - |
| DAX98_RS05310 (1109171) | 1109171..1109698 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| DAX98_RS05315 (1109695) | 1109695..1109985 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| DAX98_RS05320 (1110255) | 1110255..1110455 | - | 201 | Protein_1046 | transposase | - |
| DAX98_RS05325 (1110696) | 1110696..1111022 | + | 327 | WP_000393302.1 | hypothetical protein | - |
| DAX98_RS05330 (1111295) | 1111295..1111642 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| DAX98_RS05335 (1111627) | 1111627..1112076 | - | 450 | WP_021294302.1 | hypothetical protein | - |
| DAX98_RS05340 (1112508) | 1112508..1112951 | - | 444 | WP_001522905.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| DAX98_RS05345 (1113407) | 1113407..1114057 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1108958..1109098 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T207481 WP_000971655.1 NZ_CP077691:c1109698-1109171 [Salmonella enterica subsp. enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T207481 NZ_CP103300:2279792-2280199 [Endozoicomonas euniceicola]
ATACTGAAATTTATGCTGGATACTGACATTTCAATTTTTGTTCTCAGACACAGATCCCCAGAGTTACTGGGTGTTTTTAA
TGCTTATGACGGACAGATAGCGATTAGCTCTATCACACTCTCAGAACTGCTTCATGGTGTTGAAAAATCATCGGATCCAA
AGCAAAACCGAAATACGGTTGAAAGCTTTGTCAGTCGGCTGGAAGTGTTAGACTATACCAGCAAGGCCTCTGCCCATTAT
GGAGATATACGGGCTAACCTTGAGCGCAGGGGGCAGATTATCGGGGTAAACGATATACATATTGCCGCCCATGCCCGTAG
TGAGGGGTTGATTGCTGTGACCAATAATGTTCGTGAGTTCAGTCGTGTAGATGGCCTGCGTGTTGAAAATTGGCTGGAGC
AAGCATAG
ATACTGAAATTTATGCTGGATACTGACATTTCAATTTTTGTTCTCAGACACAGATCCCCAGAGTTACTGGGTGTTTTTAA
TGCTTATGACGGACAGATAGCGATTAGCTCTATCACACTCTCAGAACTGCTTCATGGTGTTGAAAAATCATCGGATCCAA
AGCAAAACCGAAATACGGTTGAAAGCTTTGTCAGTCGGCTGGAAGTGTTAGACTATACCAGCAAGGCCTCTGCCCATTAT
GGAGATATACGGGCTAACCTTGAGCGCAGGGGGCAGATTATCGGGGTAAACGATATACATATTGCCGCCCATGCCCGTAG
TGAGGGGTTGATTGCTGTGACCAATAATGTTCGTGAGTTCAGTCGTGTAGATGGCCTGCGTGTTGAAAATTGGCTGGAGC
AAGCATAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT207481 WP_000855694.1 NZ_CP077691:c1109985-1109695 [Salmonella enterica subsp. enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT207481 NZ_CP103300:2279553-2279792 [Endozoicomonas euniceicola]
ATGGCTCAAGGTACCGTTTTCGAAAATAACCGGACTCAGGCTGTCCGGCTTCCTGCTGAAACGCGATTTCCTGACAACAT
CAAAAAAGTCAGAGTTCGGGTGCGTGGTCAGGATCGCATCCTTTCACCAATCGGTAAGACCTGGGATTCCTTTTTCAATG
TAACGCCTGAGAATAGTGTGACCGATGACTTTATGACAGAGCGGGCCTCACAGGAACAAAAAGAGAGAGAGCAGTTTTGA
ATGGCTCAAGGTACCGTTTTCGAAAATAACCGGACTCAGGCTGTCCGGCTTCCTGCTGAAACGCGATTTCCTGACAACAT
CAAAAAAGTCAGAGTTCGGGTGCGTGGTCAGGATCGCATCCTTTCACCAATCGGTAAGACCTGGGATTCCTTTTTCAATG
TAACGCCTGAGAATAGTGTGACCGATGACTTTATGACAGAGCGGGCCTCACAGGAACAAAAAGAGAGAGAGCAGTTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |