Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 4024462..4025045 Replicon chromosome
Accession NZ_CP077683
Organism Geomonas subterranea strain RG2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KP001_RS17570 Protein ID WP_217286857.1
Coordinates 4024462..4024806 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KP001_RS17575 Protein ID WP_217286858.1
Coordinates 4024803..4025045 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP001_RS17545 (KP001_17545) 4020039..4020653 - 615 WP_217286852.1 hypothetical protein -
KP001_RS17550 (KP001_17550) 4020768..4021481 - 714 WP_217286853.1 DUF3108 domain-containing protein -
KP001_RS17555 (KP001_17555) 4021556..4021738 - 183 WP_217286854.1 hypothetical protein -
KP001_RS17560 (KP001_17560) 4022088..4023650 - 1563 WP_217286855.1 acetyl-CoA hydrolase/transferase C-terminal domain-containing protein -
KP001_RS17565 (KP001_17565) 4023856..4024449 + 594 WP_217286856.1 TetR/AcrR family transcriptional regulator -
KP001_RS17570 (KP001_17570) 4024462..4024806 - 345 WP_217286857.1 endoribonuclease MazF Toxin
KP001_RS17575 (KP001_17575) 4024803..4025045 - 243 WP_217286858.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KP001_RS17580 (KP001_17580) 4025125..4026054 - 930 WP_217286859.1 cation diffusion facilitator family transporter -
KP001_RS17585 (KP001_17585) 4026182..4026400 - 219 WP_217286860.1 hypothetical protein -
KP001_RS17590 (KP001_17590) 4026541..4027401 - 861 WP_217286861.1 DMT family transporter -
KP001_RS17595 (KP001_17595) 4027535..4027891 - 357 WP_217286862.1 TRL domain-containing protein -
KP001_RS17600 (KP001_17600) 4028139..4028963 + 825 WP_217286863.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-113)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12695.73 Da        Isoelectric Point: 8.5041

>T207476 WP_217286857.1 NZ_CP077683:c4024806-4024462 [Geomonas subterranea]
MTVMGYVPDRGEVVWLDFDPQAGHEHAGRRPAFVLSPRSYNKKTSLMLCCPITSQVKGYPFEVAVAGVTTVWGVILADQV
KSLDWQVRRPEKGGRASREVLEEVILKVRAILEG

Download         Length: 345 bp

>T207476 NZ_CP103297:22806-22955 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.99 Da        Isoelectric Point: 5.0506

>AT207476 WP_217286858.1 NZ_CP077683:c4025045-4024803 [Geomonas subterranea]
MVAKAQKWGNSLAVRLPKSIAAECGIEADSPVEITRQEGYIIIKPIVNKVFSLDALLDGINEENLHSEVSSGKPVGRELL

Download         Length: 243 bp

>AT207476 NZ_CP103297:c22761-22702 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References