Detailed information of TA system TA207475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3428943..3429604
• Replicon: chromosome
• Accession: NZ_CP077683
• Organism: Geomonas subterranea strain RG2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KP001_RS14965
• Protein ID: WP_217286397.1
• Coordinates: 3429203..3429604 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KP001_RS14960
• Protein ID: WP_217286396.1
• Coordinates: 3428943..3429188 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP001_RS14945 (KP001_14945)	3426504..3427301	+	798	WP_217286393.1	universal stress protein	-
KP001_RS14950 (KP001_14950)	3427301..3428248	+	948	WP_217286394.1	D-2-hydroxyacid dehydrogenase	-
KP001_RS14955 (KP001_14955)	3428350..3428658	-	309	WP_217286395.1	TRL-like family protein	-
KP001_RS14960 (KP001_14960)	3428943..3429188	+	246	WP_217286396.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
KP001_RS14965 (KP001_14965)	3429203..3429604	+	402	WP_217286397.1	type II toxin-antitoxin system VapC family toxin	Toxin
KP001_RS14970 (KP001_14970)	3429612..3431084	-	1473	WP_217286398.1	sigma 54-interacting transcriptional regulator	-
KP001_RS14975 (KP001_14975)	3431272..3432285	+	1014	WP_217286399.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• SpoVT-AbrB domain (12-57)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14472.65 Da
• Isoelectric Point: 4.9104

>T207475 WP_217286397.1 NZ_CP077683:3429203-3429604 [Geomonas subterranea]
MYLLDTSVFSDLIKRPGGPVTRRIASVGEDAICTSIVVACELRFGAEKKRSTSLTAKVEQIIANIEVLSLDVDADAHYAT
IRNDLELRGETIGPNDLLIAAHARSLGLILVTDNVREFARVPGLSVENWLTLP

Nucleotide

• Length: 402 bp

>T207475 NZ_CP103296:10056-10205 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9198.42 Da
• Isoelectric Point: 4.6882

>AT207475 WP_217286396.1 NZ_CP077683:3428943-3429188 [Geomonas subterranea]
MSEFTERHVRLFKNGRNQAIRIPREFELPGDEAIIHKEGNRLIIEPAKKKSLLGLLSTWGPSGEEFPDVDEGLAQLDDVE
L

Nucleotide

• Length: 246 bp

>AT207475 NZ_CP103296:c10012-9951 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT