Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3428943..3429604 Replicon chromosome
Accession NZ_CP077683
Organism Geomonas subterranea strain RG2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KP001_RS14965 Protein ID WP_217286397.1
Coordinates 3429203..3429604 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KP001_RS14960 Protein ID WP_217286396.1
Coordinates 3428943..3429188 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP001_RS14945 (KP001_14945) 3426504..3427301 + 798 WP_217286393.1 universal stress protein -
KP001_RS14950 (KP001_14950) 3427301..3428248 + 948 WP_217286394.1 D-2-hydroxyacid dehydrogenase -
KP001_RS14955 (KP001_14955) 3428350..3428658 - 309 WP_217286395.1 TRL-like family protein -
KP001_RS14960 (KP001_14960) 3428943..3429188 + 246 WP_217286396.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KP001_RS14965 (KP001_14965) 3429203..3429604 + 402 WP_217286397.1 type II toxin-antitoxin system VapC family toxin Toxin
KP001_RS14970 (KP001_14970) 3429612..3431084 - 1473 WP_217286398.1 sigma 54-interacting transcriptional regulator -
KP001_RS14975 (KP001_14975) 3431272..3432285 + 1014 WP_217286399.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(12-57)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14472.65 Da        Isoelectric Point: 4.9104

>T207475 WP_217286397.1 NZ_CP077683:3429203-3429604 [Geomonas subterranea]
MYLLDTSVFSDLIKRPGGPVTRRIASVGEDAICTSIVVACELRFGAEKKRSTSLTAKVEQIIANIEVLSLDVDADAHYAT
IRNDLELRGETIGPNDLLIAAHARSLGLILVTDNVREFARVPGLSVENWLTLP

Download         Length: 402 bp

>T207475 NZ_CP103296:10056-10205 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9198.42 Da        Isoelectric Point: 4.6882

>AT207475 WP_217286396.1 NZ_CP077683:3428943-3429188 [Geomonas subterranea]
MSEFTERHVRLFKNGRNQAIRIPREFELPGDEAIIHKEGNRLIIEPAKKKSLLGLLSTWGPSGEEFPDVDEGLAQLDDVE
L

Download         Length: 246 bp

>AT207475 NZ_CP103296:c10012-9951 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References