Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4068575..4069235 Replicon chromosome
Accession NZ_CP077680
Organism Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KTJ81_RS19700 Protein ID WP_000244756.1
Coordinates 4068575..4068988 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KTJ81_RS19705 Protein ID WP_000351186.1
Coordinates 4068969..4069235 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ81_RS19680 (4064516) 4064516..4066249 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
KTJ81_RS19685 (4066255) 4066255..4066968 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTJ81_RS19690 (4066992) 4066992..4067888 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KTJ81_RS19695 (4068001) 4068001..4068522 + 522 WP_001055885.1 flavodoxin FldB -
KTJ81_RS19700 (4068575) 4068575..4068988 - 414 WP_000244756.1 protein YgfX Toxin
KTJ81_RS19705 (4068969) 4068969..4069235 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KTJ81_RS19710 (4069485) 4069485..4070465 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
KTJ81_RS19715 (4070581) 4070581..4071240 - 660 WP_000250289.1 hemolysin III family protein -
KTJ81_RS19720 (4071404) 4071404..4071715 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KTJ81_RS19725 (4071873) 4071873..4073306 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T207472 WP_000244756.1 NZ_CP077680:c4068988-4068575 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207472 NZ_CP103295:c4285825-4285529 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207472 WP_000351186.1 NZ_CP077680:c4069235-4068969 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207472 NZ_CP103295:c4285527-4285132 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References