Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3900249..3901063 | Replicon | chromosome |
| Accession | NZ_CP077680 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | KTJ81_RS18935 | Protein ID | WP_000971653.1 |
| Coordinates | 3900536..3901063 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | KTJ81_RS18930 | Protein ID | WP_000855694.1 |
| Coordinates | 3900249..3900539 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTJ81_RS18900 (3896174) | 3896174..3896824 | - | 651 | WP_072203970.1 | type III secretion system transcriptional activator InvF | - |
| KTJ81_RS18905 (3897282) | 3897282..3897725 | + | 444 | WP_023225039.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| KTJ81_RS18910 (3898157) | 3898157..3898606 | + | 450 | WP_023225038.1 | hypothetical protein | - |
| KTJ81_RS18915 (3898591) | 3898591..3898938 | + | 348 | WP_001555786.1 | DUF1493 family protein | - |
| KTJ81_RS18920 (3899211) | 3899211..3899537 | - | 327 | WP_000393295.1 | hypothetical protein | - |
| KTJ81_RS18925 (3899778) | 3899778..3899978 | + | 201 | Protein_3699 | transposase | - |
| KTJ81_RS18930 (3900249) | 3900249..3900539 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| KTJ81_RS18935 (3900536) | 3900536..3901063 | + | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| KTJ81_RS18940 (3901136) | 3901136..3901338 | - | 203 | Protein_3702 | IS5/IS1182 family transposase | - |
| KTJ81_RS18945 (3901688) | 3901688..3902344 | + | 657 | WP_023225036.1 | protein-serine/threonine phosphatase | - |
| KTJ81_RS18950 (3902516) | 3902516..3903010 | - | 495 | WP_000424946.1 | hypothetical protein | - |
| KTJ81_RS18955 (3903037) | 3903037..3903705 | - | 669 | WP_000445914.1 | hypothetical protein | - |
| KTJ81_RS18960 (3903862) | 3903862..3904080 | - | 219 | Protein_3706 | hypothetical protein | - |
| KTJ81_RS18965 (3904291) | 3904291..3904689 | - | 399 | Protein_3707 | cytoplasmic protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 3899778..3901312 | 1534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T207471 WP_000971653.1 NZ_CP077680:3900536-3901063 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T207471 NZ_CP103295:c4151708-4151301 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT207471 WP_000855694.1 NZ_CP077680:3900249-3900539 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT207471 NZ_CP103295:c4151955-4151689 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |