Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3900249..3901063 Replicon chromosome
Accession NZ_CP077680
Organism Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag KTJ81_RS18935 Protein ID WP_000971653.1
Coordinates 3900536..3901063 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KTJ81_RS18930 Protein ID WP_000855694.1
Coordinates 3900249..3900539 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ81_RS18900 (3896174) 3896174..3896824 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
KTJ81_RS18905 (3897282) 3897282..3897725 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KTJ81_RS18910 (3898157) 3898157..3898606 + 450 WP_023225038.1 hypothetical protein -
KTJ81_RS18915 (3898591) 3898591..3898938 + 348 WP_001555786.1 DUF1493 family protein -
KTJ81_RS18920 (3899211) 3899211..3899537 - 327 WP_000393295.1 hypothetical protein -
KTJ81_RS18925 (3899778) 3899778..3899978 + 201 Protein_3699 transposase -
KTJ81_RS18930 (3900249) 3900249..3900539 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KTJ81_RS18935 (3900536) 3900536..3901063 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
KTJ81_RS18940 (3901136) 3901136..3901338 - 203 Protein_3702 IS5/IS1182 family transposase -
KTJ81_RS18945 (3901688) 3901688..3902344 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
KTJ81_RS18950 (3902516) 3902516..3903010 - 495 WP_000424946.1 hypothetical protein -
KTJ81_RS18955 (3903037) 3903037..3903705 - 669 WP_000445914.1 hypothetical protein -
KTJ81_RS18960 (3903862) 3903862..3904080 - 219 Protein_3706 hypothetical protein -
KTJ81_RS18965 (3904291) 3904291..3904689 - 399 Protein_3707 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3899778..3901312 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T207471 WP_000971653.1 NZ_CP077680:3900536-3901063 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T207471 NZ_CP103295:c4151708-4151301 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT207471 WP_000855694.1 NZ_CP077680:3900249-3900539 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT207471 NZ_CP103295:c4151955-4151689 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References