207462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2421221..2421743 Replicon chromosome
Accession NZ_CP077680
Organism Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag KTJ81_RS11535 Protein ID WP_000221345.1
Coordinates 2421221..2421505 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KTJ81_RS11540 Protein ID WP_000885424.1
Coordinates 2421495..2421743 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ81_RS11515 (2417296) 2417296..2418804 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
KTJ81_RS11520 (2418849) 2418849..2419337 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
KTJ81_RS11525 (2419530) 2419530..2420609 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KTJ81_RS11530 (2420661) 2420661..2421050 - 390 WP_000194089.1 RidA family protein -
KTJ81_RS11535 (2421221) 2421221..2421505 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTJ81_RS11540 (2421495) 2421495..2421743 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTJ81_RS11545 (2421895) 2421895..2422014 + 120 Protein_2247 type II and III secretion system -
KTJ81_RS11550 (2422100) 2422100..2422431 + 332 Protein_2248 DUF1493 family protein -
KTJ81_RS11555 (2422704) 2422704..2423612 + 909 WP_077906523.1 hypothetical protein -
KTJ81_RS24340 (2423614) 2423614..2424353 - 740 Protein_2250 hypothetical protein -
KTJ81_RS11560 (2424719) 2424719..2424907 - 189 WP_001276021.1 DUF29 family protein -
KTJ81_RS11565 (2425309) 2425309..2426217 + 909 WP_052939372.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2419530..2429089 9559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T207462 WP_000221345.1 NZ_CP077680:c2421505-2421221 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T207462 NZ_CP103295:c2349183-2349076 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT207462 WP_000885424.1 NZ_CP077680:c2421743-2421495 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT207462 NZ_CP103295:2349236-2349297 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References