Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1430143..1430763 Replicon chromosome
Accession NZ_CP077680
Organism Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KTJ81_RS06670 Protein ID WP_001280991.1
Coordinates 1430143..1430361 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KTJ81_RS06675 Protein ID WP_000344807.1
Coordinates 1430389..1430763 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ81_RS06630 (1425366) 1425366..1425935 + 570 WP_000779802.1 YbaY family lipoprotein -
KTJ81_RS06635 (1425968) 1425968..1426357 - 390 WP_023224410.1 MGMT family protein -
KTJ81_RS06645 (1426588) 1426588..1428138 - 1551 WP_000213145.1 EAL domain-containing protein -
KTJ81_RS06650 (1428363) 1428363..1428623 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KTJ81_RS06655 (1428629) 1428629..1428769 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KTJ81_RS06660 (1428825) 1428825..1429295 - 471 WP_000136183.1 YlaC family protein -
KTJ81_RS06665 (1429413) 1429413..1429964 - 552 WP_001278793.1 maltose O-acetyltransferase -
KTJ81_RS06670 (1430143) 1430143..1430361 - 219 WP_001280991.1 HHA domain-containing protein Toxin
KTJ81_RS06675 (1430389) 1430389..1430763 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KTJ81_RS06680 (1431259) 1431259..1434408 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KTJ81_RS06685 (1434431) 1434431..1435624 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207461 WP_001280991.1 NZ_CP077680:c1430361-1430143 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207461 NZ_CP103295:c1527409-1527191 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207461 WP_000344807.1 NZ_CP077680:c1430763-1430389 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207461 NZ_CP103295:c1527809-1527435 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References