Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 694120..694763 | Replicon | chromosome |
Accession | NZ_CP077680 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | B5F3H8 |
Locus tag | KTJ81_RS03315 | Protein ID | WP_000048134.1 |
Coordinates | 694120..694536 (-) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | B5F3H9 |
Locus tag | KTJ81_RS03320 | Protein ID | WP_001261294.1 |
Coordinates | 694533..694763 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KTJ81_RS03295 (689157) | 689157..690290 | + | 1134 | WP_023224151.1 | amidohydrolase/deacetylase family metallohydrolase | - |
KTJ81_RS03300 (690274) | 690274..691392 | + | 1119 | WP_023224150.1 | DgaE family pyridoxal phosphate-dependent ammonia lyase | - |
KTJ81_RS03305 (691389) | 691389..692129 | + | 741 | WP_000779255.1 | KDGP aldolase family protein | - |
KTJ81_RS03310 (692146) | 692146..694059 | + | 1914 | WP_001212148.1 | BglG family transcription antiterminator | - |
KTJ81_RS03315 (694120) | 694120..694536 | - | 417 | WP_000048134.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
KTJ81_RS03320 (694533) | 694533..694763 | - | 231 | WP_001261294.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
KTJ81_RS03325 (694931) | 694931..695395 | - | 465 | WP_001009178.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
KTJ81_RS03330 (695612) | 695612..697750 | - | 2139 | WP_000187821.1 | anaerobic ribonucleoside-triphosphate reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15135.50 Da Isoelectric Point: 8.1381
>T207457 WP_000048134.1 NZ_CP077680:c694536-694120 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK
Download Length: 417 bp
>T207457 NZ_CP103291:274872-275222 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACTATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAGAAAGTCAATGAAGCTTT
GCAAATTAGTTTAGGCCTCATTGAGTTTTAA
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACTATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAGAAAGTCAATGAAGCTTT
GCAAATTAGTTTAGGCCTCATTGAGTTTTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8878.90 Da Isoelectric Point: 4.6677
>AT207457 WP_001261294.1 NZ_CP077680:c694763-694533 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL
Download Length: 231 bp
>AT207457 NZ_CP103291:274583-274864 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2T8L749 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V4SIC2 |