Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 694120..694763 Replicon chromosome
Accession NZ_CP077680
Organism Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag KTJ81_RS03315 Protein ID WP_000048134.1
Coordinates 694120..694536 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag KTJ81_RS03320 Protein ID WP_001261294.1
Coordinates 694533..694763 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTJ81_RS03295 (689157) 689157..690290 + 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -
KTJ81_RS03300 (690274) 690274..691392 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KTJ81_RS03305 (691389) 691389..692129 + 741 WP_000779255.1 KDGP aldolase family protein -
KTJ81_RS03310 (692146) 692146..694059 + 1914 WP_001212148.1 BglG family transcription antiterminator -
KTJ81_RS03315 (694120) 694120..694536 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
KTJ81_RS03320 (694533) 694533..694763 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KTJ81_RS03325 (694931) 694931..695395 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KTJ81_RS03330 (695612) 695612..697750 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T207457 WP_000048134.1 NZ_CP077680:c694536-694120 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T207457 NZ_CP103291:274872-275222 [Peribacillus frigoritolerans]
ATTGTTGTTAAGCGTGGTGACGTATACTTCGCAGACCTTTCCCCGGTAGTCGGTTCAGAGCAGGGTGGGACCCGTCCGGT
ACTAATTTTACAAAACGATATTGGTAATCGCTTTAGTCCGACTGTGATCGTGGCAGCCATTACAGCTCAAATTCAAAAAG
CGAAATTGCCTACACATGTTGAGATTAATGCAAAAAAGTACGGATTCGAACGGGATTCCGTCATTTTATTAGAACAGATC
CGGACTATCGATAAGCAGCGTTTAACTGATAAAATTACGCATCTTGACGAACCGATGATGCAGAAAGTCAATGAAGCTTT
GCAAATTAGTTTAGGCCTCATTGAGTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT207457 WP_001261294.1 NZ_CP077680:c694763-694533 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT207457 NZ_CP103291:274583-274864 [Peribacillus frigoritolerans]
GTGTCTGAATCCAGCGCAACAAGAGAGATATTAATTCGATTACCTCAAAATTTTTTAACAGAGTTAGATGGGTATGCGAG
TGAGGAAAATGTGAATCGCAGTGAATTTATTTATCGTGCCACAAAAATGTATCTTCGCGAACGTAAAAAGAAAGAGTTTC
GTGAATCGATGAAACGCGGTTATATTGAAATGGCGGCCATTAATTTAACGATTGCTTCTGAAGCCTTCCAGGCTGAATTC
GAGGCTGGTCATTGCGTTGAACGATTAGTTAGCGGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References