Detailed information of TA system TA207456

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 555796..556577
• Replicon: chromosome
• Accession: NZ_CP077680
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A3G3E5T9
• Locus tag: KTJ81_RS02590
• Protein ID: WP_000625911.1
• Coordinates: 556086..556577 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: V7IUD2
• Locus tag: KTJ81_RS02585
• Protein ID: WP_001271379.1
• Coordinates: 555796..556089 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTJ81_RS02560	552096..553001	+	906	WP_001268192.1	YjiK family protein	-
KTJ81_RS24270	553296..553490	-	195	WP_223163373.1	hypothetical protein	-
KTJ81_RS24275	553538..553637	-	100	Protein_484	hypothetical protein	-
KTJ81_RS24280	553657..553839	+	183	WP_072106065.1	ATP-binding cassette domain-containing protein	-
KTJ81_RS02570	553832..554119	-	288	WP_072103482.1	transcriptional regulator RtsB	-
KTJ81_RS02575	554116..554991	-	876	WP_023205266.1	AraC family transcriptional regulator	-
KTJ81_RS02580	555257..555478	-	222	WP_052939504.1	hypothetical protein	-
KTJ81_RS02585	555796..556089	+	294	WP_001271379.1	DUF1778 domain-containing protein	Antitoxin
KTJ81_RS02590	556086..556577	+	492	WP_000625911.1	GNAT family N-acetyltransferase	Toxin
KTJ81_RS02595	556792..557040	+	249	Protein_491	IS481 family transposase	-
KTJ81_RS02600	557315..557542	-	228	WP_001112992.1	hypothetical protein	-
KTJ81_RS02605	558135..558419	+	285	WP_192917775.1	PapB/FocB family fimbrial expression transcriptional regulator	-
KTJ81_RS02610	558454..558993	+	540	WP_000721295.1	type 1 fimbrial protein	-
KTJ81_RS02615	559003..561441	+	2439	WP_023224120.1	F4 (K88) fimbrial usher FaeD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeC / faeD / faeE / faeF / faeH / faeI	553832..569599	15767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17663.44 Da
• Isoelectric Point: 7.2655

>T207456 WP_000625911.1 NZ_CP077680:556086-556577 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T207456 NZ_CP103290:3733720-3734070 [Bacillus atrophaeus]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10938.54 Da
• Isoelectric Point: 9.8590

>AT207456 WP_001271379.1 NZ_CP077680:555796-556089 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT207456 NZ_CP103290:3733434-3733715 [Bacillus atrophaeus]
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Toxin

• AlphaFold DB: A0A3G3E5T9

Antitoxin

• AlphaFold DB: V7IUD2