Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 555796..556577 | Replicon | chromosome |
| Accession | NZ_CP077680 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain YZ20MCS16 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3G3E5T9 |
| Locus tag | KTJ81_RS02590 | Protein ID | WP_000625911.1 |
| Coordinates | 556086..556577 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | V7IUD2 |
| Locus tag | KTJ81_RS02585 | Protein ID | WP_001271379.1 |
| Coordinates | 555796..556089 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTJ81_RS02560 (552096) | 552096..553001 | + | 906 | WP_001268192.1 | YjiK family protein | - |
| KTJ81_RS24270 (553296) | 553296..553490 | - | 195 | WP_223163373.1 | hypothetical protein | - |
| KTJ81_RS24275 (553538) | 553538..553637 | - | 100 | Protein_484 | hypothetical protein | - |
| KTJ81_RS24280 (553657) | 553657..553839 | + | 183 | WP_072106065.1 | ATP-binding cassette domain-containing protein | - |
| KTJ81_RS02570 (553832) | 553832..554119 | - | 288 | WP_072103482.1 | transcriptional regulator RtsB | - |
| KTJ81_RS02575 (554116) | 554116..554991 | - | 876 | WP_023205266.1 | AraC family transcriptional regulator | - |
| KTJ81_RS02580 (555257) | 555257..555478 | - | 222 | WP_052939504.1 | hypothetical protein | - |
| KTJ81_RS02585 (555796) | 555796..556089 | + | 294 | WP_001271379.1 | DUF1778 domain-containing protein | Antitoxin |
| KTJ81_RS02590 (556086) | 556086..556577 | + | 492 | WP_000625911.1 | GNAT family N-acetyltransferase | Toxin |
| KTJ81_RS02595 (556792) | 556792..557040 | + | 249 | Protein_491 | IS481 family transposase | - |
| KTJ81_RS02600 (557315) | 557315..557542 | - | 228 | WP_001112992.1 | hypothetical protein | - |
| KTJ81_RS02605 (558135) | 558135..558419 | + | 285 | WP_192917775.1 | PapB/FocB family fimbrial expression transcriptional regulator | - |
| KTJ81_RS02610 (558454) | 558454..558993 | + | 540 | WP_000721295.1 | type 1 fimbrial protein | - |
| KTJ81_RS02615 (559003) | 559003..561441 | + | 2439 | WP_023224120.1 | F4 (K88) fimbrial usher FaeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | faeC / faeD / faeE / faeF / faeH / faeI | 553832..569599 | 15767 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17663.44 Da Isoelectric Point: 7.2655
>T207456 WP_000625911.1 NZ_CP077680:556086-556577 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T207456 NZ_CP103290:3733720-3734070 [Bacillus atrophaeus]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGAGTGCGCCCGGT
TTTGGTGATTCAAAATGATATCGGAAATCGCTTTAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATTTTGCTGGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATTAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10938.54 Da Isoelectric Point: 9.8590
>AT207456 WP_001271379.1 NZ_CP077680:555796-556089 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT207456 NZ_CP103290:3733434-3733715 [Bacillus atrophaeus]
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAACAACCGAAATGATGATTAGCTTGCCGGAAGCACTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTAATATCACAAGCAGTGAGAGCCTATGTCAGCGAACGCACAACTCGTCACAACC
GTGATTTGATGAGACGCGGATATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAAGCTCATTTTGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3E5T9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V7IUD2 |