Detailed information of TA system TA207452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 672966..674434
• Replicon: chromosome
• Accession: NZ_CP077679
• Organism: Stenotrophomonas maltophilia strain Col1

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: KS456_RS02990
• Protein ID: WP_254113624.1
• Coordinates: 672966..673835 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: KS456_RS02995
• Protein ID: WP_217015133.1
• Coordinates: 673832..674434 (-)
• Length: 201 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KS456_RS02970	669018..669662	-	645	WP_217015129.1	metal-dependent hydrolase	-
KS456_RS02975	669809..670177	-	369	WP_026347139.1	YraN family protein	-
KS456_RS02980	670167..671888	-	1722	WP_217015130.1	penicillin-binding protein activator	-
KS456_RS02985	671970..672788	+	819	WP_005408070.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
KS456_RS02990	672966..673835	-	870	WP_254113624.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KS456_RS02995	673832..674434	-	603	WP_217015133.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KS456_RS03005	675127..675606	-	480	WP_053442516.1	DM13 domain-containing protein	-
KS456_RS03010	675708..676460	-	753	WP_197643490.1	NRDE family protein	-
KS456_RS03015	676829..677230	+	402	WP_008266948.1	division/cell wall cluster transcriptional repressor MraZ	-
KS456_RS03020	677245..678213	+	969	WP_197654290.1	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	-
KS456_RS03025	678210..678473	+	264	WP_005412242.1	cell division protein FtsL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (40-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (11-52)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32960.60 Da
• Isoelectric Point: 6.4998

>T207452 WP_254113624.1 NZ_CP077679:c673835-672966 [Stenotrophomonas maltophilia]
VTHSPPLPQRVASIRQRLLDRARSRGEDFQFVLDRFAVERLLYRLSTSRYRDQFLLKGAMFFAVWFDMPHRPTRDADFLR
FGTADPDHLLHIVRSLCAIPDDDGLCFDPGSIAIEATREEAEYEGLRMRLTAHLGRSRCHVQWDVGFGDAVTPPPQEIAY
PVMLDDFHAPFLRVYPRETVFAEKLEAIAALGVANSRMKDFFDLLALVREDAMDRPHLVAAIGATFDRRRTPAPTPLPYG
LTQSFAADTQKQTQWRAFLRRNRLIAPDLSSVIAEIAEYLDTLDTTVQS

Nucleotide

• Length: 870 bp

>T207452 NZ_CP103250:c3324212-3323961 [Bacteroides uniformis]
ATGGGTACAAAAGAGAAGTTGATAGAACGCTTTAAAAGCCAGCCAAAAGATTTTAATTGGGATGAGCTTGTACGCTTGTT
CTCCATTTTCGGATATAAGATAGATAACAAAGGAAAAACAAGTGGGTCACGTGTCATTTTCGCAAAAGGGGAAAGCTCGT
ACACTGCGCATAAGCCACATCCAGGAAGTATCGTAAAAGGGTATGTAATGAAACAAGTATTTGAATTTCTGACTAAAAAT
AAATTAATATGA

Antitoxin

Protein

• Length: 201 a.a.
• Molecular weight: 22406.14 Da
• Isoelectric Point: 11.5334

>AT207452 WP_217015133.1 NZ_CP077679:c674434-673832 [Stenotrophomonas maltophilia]
MGNAEAKARKLLRRAGTLRARELVTAGIARTQLTRLVEAGALIRLSRGVYTLAERNSDDTDDGLRVIAERLPHPRLCLLS
ALRLHGLTTQAPFERWVSIGNSDRAPRIDWPPLRVVRMSATTLNSGLEERRVGRRLIYVSNVAKTVVDCFKFRNLVGLDV
ALEALRDALHNRATTPDALMKYARICRVARLMRPYLDALA

Nucleotide

• Length: 603 bp

>AT207452 NZ_CP103250:c3323964-3323620 [Bacteroides uniformis]
ATGAAAACATTGACTTACAAAGGTTACATAGGAAGTATTGAGATAAGCGATGAAGATAATTGCCTATTTGGAAAAGTCCT
TGATTTGCCAAAAGATACAATGATTTCGTATGAAGGTGAAACTGTATCTGAATTGAAAGAGGATTTTAAAGGAGCTGTGG
ATGATTATATAGCATATTGTAAGGAAGCCGGAATTACACCGCGTAAAAGTTATTCTGGTTCCCTGAACATACGAATTTCC
CCAGAGGTACATAGCAAAATTGCCATTCTCGCCCAACAGGCTGGAATATCAATAAACGCTTTTATTAAATCAGCCGTAGA
AAAGCAAGTTGCAACTATGTTATAA