Detailed information of TA system TA207451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 250824..251461
• Replicon: chromosome
• Accession: NZ_CP077679
• Organism: Stenotrophomonas maltophilia strain Col1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: KS456_RS01115
• Protein ID: WP_019337795.1
• Coordinates: 251171..251461 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M5CST9
• Locus tag: KS456_RS01110
• Protein ID: WP_004136660.1
• Coordinates: 250824..251132 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KS456_RS01090	246409..247299	+	891	WP_217014847.1	3-hydroxyisobutyrate dehydrogenase	-
KS456_RS01095	247587..248012	-	426	WP_217014849.1	organic hydroperoxide resistance protein	-
KS456_RS01100	248124..249104	-	981	WP_021203767.1	cation transporter	-
KS456_RS01105	249313..250767	+	1455	WP_217014851.1	SulP family inorganic anion transporter	-
KS456_RS01110	250824..251132	-	309	WP_004136660.1	putative addiction module antidote protein	Antitoxin
KS456_RS01115	251171..251461	-	291	WP_019337795.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KS456_RS01120	251709..252740	+	1032	WP_217014853.1	tRNA dihydrouridine(20/20a) synthase DusA	-
KS456_RS01125	252953..253327	+	375	WP_217014855.1	hypothetical protein	-
KS456_RS01130	253401..254084	+	684	WP_004136763.1	response regulator transcription factor	-
KS456_RS01135	254110..255534	+	1425	WP_032128221.1	sensor histidine kinase	-
KS456_RS01140	255619..256407	-	789	WP_197578923.1	zinc-dependent peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	250824..261313	10489

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-91)

Antitoxin

• Uncharacterized protein HI1420 (16-94)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10755.28 Da
• Isoelectric Point: 11.7461

>T207451 WP_019337795.1 NZ_CP077679:c251461-251171 [Stenotrophomonas maltophilia]
MATLQATETFTRWLRGLNDSGARAVIVERLQRVSRGLEGDVRSVGHGVSELRINHGPGYRVYFTRRGRSIVVLLHGGDKS
SQRRDIEKAVRLADLL

Nucleotide

• Length: 291 bp

>T207451 NZ_CP103242:3478644-3478904 [Parabacteroides distasonis]
ATGGGTTCTAAAGAAAAGTTGATCGAGCATTTTTGTAAACTACCTAAAGATTTCACCTACGAGGAAACTTTAAAATTGCT
TTCTTCTTATGGCTATAACGAGCATAATAAAGGTGCAACGTCAGGTTCTCGCGTGAGATTTAAAAATGAACAGACGGGAC
AATATATTGATATTCATAAACCGCATCCGGGTAGTATTATGAAGGAGTGGATGATGAAAGCGATATATCAGCATTTAAAA
AGTAATGGTTTAATTAAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10662.10 Da
• Isoelectric Point: 6.2132

>AT207451 WP_004136660.1 NZ_CP077679:c251132-250824 [Stenotrophomonas maltophilia]
MSKLKTIPFDPADYLDDDVAIATYLSEALAAGDAGHFQEALGTVARARGMGGVAEVSGLGRESLYKALRPGAHPRFDTVQ
RVLSALGVHLIVQADKQPAGTA

Nucleotide

• Length: 309 bp

>AT207451 NZ_CP103242:3478916-3479257 [Parabacteroides distasonis]
ATGGACTATTTGGAATACAAAGGTTATAAAGGTTCTGTTGAGTACAGTAAGGCTGATAACTGTCTTTGCGGAAAGGTACT
TGGTATGAGTAAAGATTTAATTCTTTATGAAGGTAATACTATCGATGAACTTCGTGCGGATTTTGAAGCCGGAGTAGAAA
GCTATCTTGCCGGCTGTTTGGCTGATGGCGTGGAACCTCGTAAACCTTATAGTGGCACGTTAAATATCCGTATTTCACCA
GAAATACATAGCCGAATCGCAGCATTGGCGCAAGAGGCGGGAACTACGATTAACGGGTATATAAAACAGGCTTTGGAGAA
TCAGTTGAAGCTTGCCCATTAA

Structures

Antitoxin

• AlphaFold DB: M5CST9