Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2380370..2380955 Replicon chromosome
Accession NZ_CP077678
Organism Pseudomonas chlororaphis strain X8

Toxin (Protein)


Gene name PumA Uniprot ID A0A7S5HMS4
Locus tag KS461_RS11110 Protein ID WP_016705075.1
Coordinates 2380662..2380955 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7ICX6
Locus tag KS461_RS11105 Protein ID WP_038580367.1
Coordinates 2380370..2380660 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KS461_RS11095 (KS461_11070) 2377883..2379265 + 1383 WP_258257276.1 efflux transporter outer membrane subunit -
KS461_RS11100 (KS461_11075) 2379384..2379971 + 588 WP_124308120.1 hypothetical protein -
KS461_RS11105 (KS461_11080) 2380370..2380660 - 291 WP_038580367.1 putative addiction module antidote protein Antitoxin
KS461_RS11110 (KS461_11085) 2380662..2380955 - 294 WP_016705075.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KS461_RS11115 (KS461_11090) 2381190..2382584 - 1395 WP_258257277.1 VOC family protein -
KS461_RS11120 (KS461_11095) 2382849..2383973 + 1125 WP_258257279.1 diguanylate cyclase -
KS461_RS11125 (KS461_11100) 2384067..2385311 + 1245 WP_258257281.1 M20/M25/M40 family metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10699.27 Da        Isoelectric Point: 10.0959

>T207448 WP_016705075.1 NZ_CP077678:c2380955-2380662 [Pseudomonas chlororaphis]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

>T207448 NZ_CP103068:6250408-6250677 [Bacteroides sp. BFG-257]
ATGAAAGTAATATTTTCACCTCTTGCTATGGAGCAATGGGAGTACTGGAAGAAAAACAATCCTAATATTGCCAAACGCAT
CAAGAAGATTCTTCTCGACATTAGAGAGCATCCTTATACAGGAATCGCAAAGCCAGAACCTCTTAAATATGATTTAGCGG
GTAAATGGTCAAGACGCATCAATGAGGAACATAGGATTATTTACTCTGTAAATGATGACAGAATAGAGATTGATATACTA
TCAATGAGATACCATTACTCCAAGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10239.78 Da        Isoelectric Point: 8.0096

>AT207448 WP_038580367.1 NZ_CP077678:c2380660-2380370 [Pseudomonas chlororaphis]
MSDTLVPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVSRG

Download         Length: 291 bp

>AT207448 NZ_CP103068:6250157-6250411 [Bacteroides sp. BFG-257]
ATGAGAACAGCCAATTACACCGATTTAAGAGCGAATCTTAAAGGTTACATTGATTCAGTGATTGATGACTATGATACTGT
AATCGTCAATCGCGGTAATGGTAAAGGAGTAGTGATGATTTCCCTTGATGAATACAATTCACTGAAAGAGACTGAATATA
TCATGTCCTCACCTGCAACAATGGAAGCTATACGTCAAGGCGAAGAAGATATAAAGAATGGCAAGGGAATAGAGGTAGAC
TTAGATGAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5HMS4

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7ICX6

References