Detailed information of TA system TA207447

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2362311..2362930
• Replicon: chromosome
• Accession: NZ_CP077678
• Organism: Pseudomonas chlororaphis strain X8

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KS461_RS11025
• Protein ID: WP_258257268.1
• Coordinates: 2362748..2362930 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KS461_RS11020
• Protein ID: WP_110175432.1
• Coordinates: 2362311..2362712 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KS461_RS11005 (KS461_10980)	2358175..2360064	+	1890	WP_258257265.1	PAS domain S-box protein	-
KS461_RS11010 (KS461_10985)	2360061..2360696	+	636	WP_053260452.1	response regulator transcription factor	-
KS461_RS11015 (KS461_10990)	2360790..2361554	+	765	WP_124298953.1	hypothetical protein	-
KS461_RS11020 (KS461_10995)	2362311..2362712	-	402	WP_110175432.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KS461_RS11025 (KS461_11000)	2362748..2362930	-	183	WP_258257268.1	type II toxin-antitoxin system HicA family toxin	Toxin
KS461_RS11030 (KS461_11005)	2363295..2363576	-	282	WP_038580384.1	hypothetical protein	-
KS461_RS11035 (KS461_11010)	2364251..2364706	+	456	WP_053268621.1	hypothetical protein	-
KS461_RS11040 (KS461_11015)	2364997..2365818	+	822	WP_258257269.1	hypothetical protein	-
KS461_RS11045 (KS461_11020)	2366154..2366702	-	549	WP_258257270.1	YniB family protein	-
KS461_RS11050 (KS461_11025)	2367054..2367707	+	654	WP_258257272.1	peroxiredoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2356370..2368738	12368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6806.93 Da
• Isoelectric Point: 10.8243

>T207447 WP_258257268.1 NZ_CP077678:c2362930-2362748 [Pseudomonas chlororaphis]
VQSRQFIKELEAAGWVLERVTGSHHLFTHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Nucleotide

• Length: 183 bp

>T207447 NZ_CP103066:2677867-2678046 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14609.56 Da
• Isoelectric Point: 4.6017

>AT207447 WP_110175432.1 NZ_CP077678:c2362712-2362311 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRTNPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT207447 NZ_CP103066:c2678192-2677970 [Bacillus subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC