Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 5159298..5159890 Replicon chromosome
Accession NZ_CP077673
Organism Klebsiella sp. PL-2018

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag MKleb_RS24260 Protein ID WP_004105955.1
Coordinates 5159298..5159672 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag MKleb_RS24265 Protein ID WP_004105957.1
Coordinates 5159669..5159890 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKleb_RS24240 (MKleb_4745) 5154647..5155990 - 1344 WP_025108308.1 glycoside-pentoside-hexuronide (GPH):cation symporter -
MKleb_RS24245 (MKleb_4746) 5156215..5156964 + 750 WP_224226526.1 AraC family transcriptional regulator -
MKleb_RS24250 (MKleb_4747) 5157093..5158736 + 1644 WP_025108310.1 glycoside hydrolase family 43 protein -
MKleb_RS24255 (MKleb_4748) 5158815..5159318 + 504 WP_025108311.1 M48 family metallopeptidase -
MKleb_RS24260 (MKleb_4749) 5159298..5159672 - 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MKleb_RS24265 (MKleb_4750) 5159669..5159890 - 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MKleb_RS24270 (MKleb_4751) 5160050..5161039 + 990 WP_025108312.1 Gfo/Idh/MocA family oxidoreductase -
MKleb_RS24275 (MKleb_4752) 5161290..5162258 + 969 WP_014839614.1 TerC family protein -
MKleb_RS24280 (MKleb_4753) 5162513..5163760 + 1248 WP_004105963.1 serine/threonine transporter SstT -
MKleb_RS24285 (MKleb_4754) 5163779..5164333 - 555 WP_014226934.1 YgjV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T207439 WP_004105955.1 NZ_CP077673:c5159672-5159298 [Klebsiella sp. PL-2018]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T207439 NZ_CP103057:4070485-4070892 [Sphingomonas sp. ZFBP2030]
ATGCCCGGTAGCTTCTTCGACAGCAATGTGCCGCTGTCTGTCGCGGTTGGCGATGACGCGAAGGCGAATCTGGCCGAGCA
GCTCTTATCTAGTGGCGGCATCGTAAGTGTTCAGGTGTTGAACGAAGTCGCCAATGTTGCGTTGCGCAAATACGGGTTCA
CTATTCCCGAGGTCGTGACGTTTATCGACAGCCTGCGTTTCGTCGTGAAGGTGGTGCCGGTGACGGTCGAGACGCATGAA
GTCGCGTTGATCGTTCGGGAGCGTCACCGTTTCGCATTTCACGATTGTGCGATCGTCGCTGCAGCATTGCTCGCCGATTG
CGAGACGCTGTGGTCGGAGGACATGCACGACGGGCTTGTCGTCGACGGGCGGCTTACGATCCGCAACCCGTTTGCGGGGG
CGGCGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT207439 WP_004105957.1 NZ_CP077673:c5159890-5159669 [Klebsiella sp. PL-2018]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT207439 NZ_CP103057:4070265-4070495 [Sphingomonas sp. ZFBP2030]
ATGCAGGTTGCGAAATGGGGCAATAGCCTCGCGGTTCGACTGCCGAAGCACGTTGTTCTTGCGCTGGATTTGAAGGCCGG
AGACGACGTTACGCTGCGCGCGCGGGAGCCCGGCACGTTGGACGTCTCGAAGACGATGACCCGCGAGGAAGCGCTGATGA
ACTTGCGGCGCTTTCGCGGGATGATCCCGGCGGACTTCAAGTTCGACCGCGACGAGGCCAATGCCCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References