Detailed information of TA system TA207438

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4887849..4888506
• Replicon: chromosome
• Accession: NZ_CP077673
• Organism: Klebsiella sp. PL-2018

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MKleb_RS22950
• Protein ID: WP_217076205.1
• Coordinates: 4887849..4888259 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: H3N295
• Locus tag: MKleb_RS22955
• Protein ID: WP_004124953.1
• Coordinates: 4888240..4888506 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKleb_RS22930 (MKleb_4488)	4883826..4885559	-	1734	WP_025105972.1	single-stranded-DNA-specific exonuclease RecJ	-
MKleb_RS22935 (MKleb_4489)	4885565..4886278	-	714	WP_004854054.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
MKleb_RS22940 (MKleb_4490)	4886301..4887197	-	897	WP_004105555.1	site-specific tyrosine recombinase XerD	-
MKleb_RS22945 (MKleb_4491)	4887319..4887840	+	522	WP_014226792.1	flavodoxin FldB	-
MKleb_RS22950 (MKleb_4492)	4887849..4888259	-	411	WP_217076205.1	protein YgfX	Toxin
MKleb_RS22955 (MKleb_4493)	4888240..4888506	-	267	WP_004124953.1	FAD assembly factor SdhE	Antitoxin
MKleb_RS22960 (MKleb_4494)	4888751..4889734	+	984	WP_025105971.1	tRNA-modifying protein YgfZ	-
MKleb_RS22965 (MKleb_4495)	4889926..4892724	+	2799	WP_025105970.1	transcriptional regulator DagR	-
MKleb_RS22970 (MKleb_4496)	4892845..4893270	+	426	WP_004854067.1	PTS sugar transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16156.05 Da
• Isoelectric Point: 10.6531

>T207438 WP_217076205.1 NZ_CP077673:c4888259-4887849 [Klebsiella sp. PL-2018]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVIYSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Nucleotide

• Length: 411 bp

>T207438 NZ_CP103054:316162-316305 [Pseudomonas mosselii]
CTGGTGCGTTCGAAAGGCAGCCACCATCACTTCAAGCATCCCGAAAAGGCAGGCCTGGTCACCATCCCGCATCCAAAGAA
AGACCTGCTGCCGGCCACTGCGGCCAGCATCCTGCGCCAGGCGCGGATCGGCTATGCCAGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10411.88 Da
• Isoelectric Point: 5.1296

>AT207438 WP_004124953.1 NZ_CP077673:c4888506-4888240 [Klebsiella sp. PL-2018]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT207438 NZ_CP103054:316323-316736 [Pseudomonas mosselii]
ATGTTGTTCCCCATTGCGATTCTCCCCGGTGACGATCAACACGCCTGGGGTGTGGAAGTCCCTGACATTCCGGGCTGTTT
CTCGGCCGGCGAGGACCTCGACAACGCCATTGCCATGGCCCGTGAAGCCATCGAAGGCCACCTCGAACTGCTGGCCCAGG
ACCAGCAGGAGATCCCCAAGGCCAGCCTGGTCAGCGTGCACGCGGCCAATCCGGCCTATGCCGGCTGTACCTGGGCGCTG
ATCGACATCGACATCACCCGTTACCTGGGCAAGGCCGAGAAGCTCAACATCACACTGCCGGCGTACCTGCTTACCCGCAT
CGACTCCTACGTGCAGAACCATCCGGAGCACAAGAGCCGTTCGGGCTTTTTGGCCGAAGCGGCGCTCAGGATCCTGCAGG
GGGACTGCAAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3H3L9