Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
| Location | 4207451..4208082 | Replicon | chromosome |
| Accession | NZ_CP077673 | ||
| Organism | Klebsiella sp. PL-2018 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1Q8YTV3 |
| Locus tag | MKleb_RS19610 | Protein ID | WP_012542177.1 |
| Coordinates | 4207906..4208082 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MKleb_RS19605 | Protein ID | WP_217076115.1 |
| Coordinates | 4207451..4207858 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKleb_RS19565 | 4202624..4202905 | - | 282 | WP_217076108.1 | hypothetical protein | - |
| MKleb_RS19570 (MKleb_3831) | 4202880..4203194 | - | 315 | WP_217076111.1 | hypothetical protein | - |
| MKleb_RS19575 (MKleb_3832) | 4203203..4203694 | - | 492 | WP_217076112.1 | DUF2514 domain-containing protein | - |
| MKleb_RS19580 (MKleb_3833) | 4203916..4204134 | - | 219 | WP_217076767.1 | hypothetical protein | - |
| MKleb_RS19585 (MKleb_3834) | 4204198..4204440 | - | 243 | WP_228740750.1 | hypothetical protein | - |
| MKleb_RS29970 | 4204641..4204778 | - | 138 | WP_228740752.1 | hypothetical protein | - |
| MKleb_RS19590 (MKleb_3835) | 4204802..4205221 | - | 420 | WP_217076113.1 | structural protein | - |
| MKleb_RS19595 (MKleb_3836) | 4205208..4205537 | - | 330 | WP_217076771.1 | phage holin, lambda family | - |
| MKleb_RS19600 (MKleb_3838) | 4206322..4206852 | - | 531 | WP_217076114.1 | KilA-N domain-containing protein | - |
| MKleb_RS19605 (MKleb_3839) | 4207451..4207858 | - | 408 | WP_217076115.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MKleb_RS19610 (MKleb_3840) | 4207906..4208082 | - | 177 | WP_012542177.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MKleb_RS19615 (MKleb_3842) | 4208505..4209515 | + | 1011 | WP_217076116.1 | hypothetical protein | - |
| MKleb_RS19620 (MKleb_3843) | 4209529..4209906 | - | 378 | WP_217076117.1 | antiterminator Q family protein | - |
| MKleb_RS19625 (MKleb_3844) | 4209903..4210520 | - | 618 | WP_217076119.1 | recombination protein NinG | - |
| MKleb_RS19630 (MKleb_3845) | 4210517..4210939 | - | 423 | WP_217076121.1 | hypothetical protein | - |
| MKleb_RS19635 (MKleb_3846) | 4210936..4211898 | - | 963 | WP_217076122.1 | helix-turn-helix domain-containing protein | - |
| MKleb_RS30155 | 4211895..4212452 | - | 558 | WP_267460481.1 | Rha family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4176106..4224543 | 48437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6632.83 Da Isoelectric Point: 11.0174
>T207437 WP_012542177.1 NZ_CP077673:c4208082-4207906 [Klebsiella sp. PL-2018]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK
Download Length: 177 bp
>T207437 NZ_CP102995:c89770-89459 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 15099.09 Da Isoelectric Point: 4.2956
>AT207437 WP_217076115.1 NZ_CP077673:c4207858-4207451 [Klebsiella sp. PL-2018]
MRYPLIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDERREIPAPSDEGEAFVEVPSSVAAKVLLL
NRLVNTNTSNAELARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQSMEIVVR
MRYPLIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDERREIPAPSDEGEAFVEVPSSVAAKVLLL
NRLVNTNTSNAELARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQSMEIVVR
Download Length: 408 bp
>AT207437 NZ_CP102995:c89462-89043 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|