Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
| Location | 3754910..3755500 | Replicon | chromosome |
| Accession | NZ_CP077673 | ||
| Organism | Klebsiella sp. PL-2018 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | A0A1F2LYA2 |
| Locus tag | MKleb_RS17550 | Protein ID | WP_008804165.1 |
| Coordinates | 3754910..3755242 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | MKleb_RS17555 | Protein ID | WP_109240840.1 |
| Coordinates | 3755243..3755500 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKleb_RS17510 (MKleb_3429) | 3750601..3751269 | + | 669 | WP_217076033.1 | DNA-binding protein | - |
| MKleb_RS17515 (MKleb_3430) | 3751363..3751830 | + | 468 | WP_080893861.1 | DUF4756 family protein | - |
| MKleb_RS17520 (MKleb_3431) | 3751879..3752115 | - | 237 | WP_217076034.1 | DNA-binding protein | - |
| MKleb_RS17525 (MKleb_3432) | 3752178..3752474 | - | 297 | WP_000032534.1 | hypothetical protein | - |
| MKleb_RS17530 (MKleb_3433) | 3752545..3752781 | - | 237 | WP_080893859.1 | hypothetical protein | - |
| MKleb_RS17535 (MKleb_3434) | 3752847..3753164 | - | 318 | WP_000030115.1 | hypothetical protein | - |
| MKleb_RS17540 (MKleb_3435) | 3753304..3753522 | - | 219 | WP_080893858.1 | AlpA family transcriptional regulator | - |
| MKleb_RS17545 (MKleb_3436) | 3753699..3754559 | - | 861 | WP_217076036.1 | DUF6387 family protein | - |
| MKleb_RS17550 (MKleb_3437) | 3754910..3755242 | - | 333 | WP_008804165.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MKleb_RS17555 (MKleb_3438) | 3755243..3755500 | - | 258 | WP_109240840.1 | antitoxin | Antitoxin |
| MKleb_RS17560 | 3755852..3756058 | - | 207 | WP_074177945.1 | helix-turn-helix domain-containing protein | - |
| MKleb_RS17565 | 3756123..3756422 | - | 300 | WP_162557623.1 | hypothetical protein | - |
| MKleb_RS17570 (MKleb_3439) | 3756571..3757485 | - | 915 | WP_109240841.1 | LysR family transcriptional regulator | - |
| MKleb_RS17575 (MKleb_3440) | 3757586..3758584 | + | 999 | WP_109240842.1 | aldo/keto reductase | - |
| MKleb_RS17580 (MKleb_3441) | 3758622..3759548 | - | 927 | WP_025106068.1 | LysR substrate-binding domain-containing protein | - |
| MKleb_RS17585 (MKleb_3442) | 3759728..3760333 | + | 606 | WP_004852315.1 | glutathione S-transferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3747538..3766600 | 19062 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11867.71 Da Isoelectric Point: 10.1839
>T207436 WP_008804165.1 NZ_CP077673:c3755242-3754910 [Klebsiella sp. PL-2018]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS
Download Length: 333 bp
>T207436 NZ_CP102995:44021-44446 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9449.91 Da Isoelectric Point: 4.4737
>AT207436 WP_109240840.1 NZ_CP077673:c3755500-3755243 [Klebsiella sp. PL-2018]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMNEEEREWVDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMNEEEREWVDAPAV
GKEIL
Download Length: 258 bp
>AT207436 NZ_CP102995:43794-44024 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|