Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 1176616..1177435 Replicon chromosome
Accession NZ_CP077673
Organism Klebsiella sp. PL-2018

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag MKleb_RS05465 Protein ID WP_004110819.1
Coordinates 1176616..1176873 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A7H4NQD3
Locus tag MKleb_RS05470 Protein ID WP_064378312.1
Coordinates 1176884..1177435 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKleb_RS05450 (MKleb_1048) 1172292..1173068 - 777 WP_004847986.1 Uxu operon transcriptional regulator -
MKleb_RS05455 (MKleb_1049) 1173207..1174682 - 1476 WP_128696736.1 fructuronate reductase -
MKleb_RS05460 (MKleb_1050) 1174756..1175940 - 1185 WP_014228054.1 mannonate dehydratase -
MKleb_RS05465 (MKleb_1051) 1176616..1176873 + 258 WP_004110819.1 YjhX family toxin Toxin
MKleb_RS05470 (MKleb_1052) 1176884..1177435 + 552 WP_064378312.1 N-acetyltransferase Antitoxin
MKleb_RS29845 1177549..1177959 + 411 Protein_1048 class I SAM-dependent methyltransferase -
MKleb_RS29850 1178335..1179081 + 747 WP_224322392.1 class I SAM-dependent methyltransferase -
MKleb_RS05480 (MKleb_1054) 1179206..1180546 - 1341 WP_163586119.1 carbohydrate porin -
MKleb_RS05485 (MKleb_1055) 1180668..1182065 - 1398 WP_014228060.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T207426 WP_004110819.1 NZ_CP077673:1176616-1176873 [Klebsiella sp. PL-2018]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T207426 NZ_CP102993:661245-661586 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19976.78 Da        Isoelectric Point: 6.4897

>AT207426 WP_064378312.1 NZ_CP077673:1176884-1177435 [Klebsiella sp. PL-2018]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQTVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRAGQIQCARALMKPEHWRE

Download         Length: 552 bp

>AT207426 NZ_CP102993:660907-661224 [Klebsiella pneumoniae]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATGACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4NQD3

References