207418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4075922..4076438 Replicon chromosome
Accession NZ_CP077670
Organism Salmonella enterica strain S90

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag KTP13_RS19805 Protein ID WP_000220577.1
Coordinates 4075922..4076206 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KTP13_RS19810 Protein ID WP_000212724.1
Coordinates 4076196..4076438 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP13_RS19790 (4071038) 4071038..4072690 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
KTP13_RS19795 (4073099) 4073099..4075237 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
KTP13_RS19800 (4075454) 4075454..4075918 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KTP13_RS19805 (4075922) 4075922..4076206 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTP13_RS19810 (4076196) 4076196..4076438 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KTP13_RS19815 (4076516) 4076516..4078429 - 1914 WP_023226980.1 BglG family transcription antiterminator -
KTP13_RS19820 (4078446) 4078446..4079186 - 741 WP_000779254.1 KDGP aldolase family protein -
KTP13_RS19825 (4079183) 4079183..4080301 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KTP13_RS19830 (4080285) 4080285..4081418 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T207418 WP_000220577.1 NZ_CP077670:c4076206-4075922 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207418 NZ_CP102987:c4719675-4719391 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207418 WP_000212724.1 NZ_CP077670:c4076438-4076196 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207418 NZ_CP102987:c4719907-4719665 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References