Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3343052..3343672 Replicon chromosome
Accession NZ_CP077670
Organism Salmonella enterica strain S90

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KTP13_RS16295 Protein ID WP_001280991.1
Coordinates 3343454..3343672 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KTP13_RS16290 Protein ID WP_000344807.1
Coordinates 3343052..3343426 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP13_RS16280 (3338191) 3338191..3339384 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KTP13_RS16285 (3339407) 3339407..3342556 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
KTP13_RS16290 (3343052) 3343052..3343426 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KTP13_RS16295 (3343454) 3343454..3343672 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KTP13_RS16300 (3343851) 3343851..3344402 + 552 WP_001278793.1 maltose O-acetyltransferase -
KTP13_RS16305 (3344520) 3344520..3344990 + 471 WP_000136181.1 YlaC family protein -
KTP13_RS16310 (3345046) 3345046..3345186 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KTP13_RS16315 (3345192) 3345192..3345452 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KTP13_RS16320 (3345677) 3345677..3347227 + 1551 WP_023210786.1 EAL domain-containing protein -
KTP13_RS16330 (3347458) 3347458..3347847 + 390 WP_000961285.1 MGMT family protein -
KTP13_RS16335 (3347880) 3347880..3348449 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207414 WP_001280991.1 NZ_CP077670:3343454-3343672 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207414 NZ_CP102987:1882618-1882720 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207414 WP_000344807.1 NZ_CP077670:3343052-3343426 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207414 NZ_CP102987:c1882727-1882582 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References