Detailed information of TA system TA207403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 823079..823704
• Replicon: chromosome
• Accession: NZ_CP077670
• Organism: Salmonella enterica strain S90

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KTP13_RS03980
• Protein ID: WP_000911337.1
• Coordinates: 823306..823704 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: KTP13_RS03975
• Protein ID: WP_000557545.1
• Coordinates: 823079..823306 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP13_RS03945 (818124)	818124..819641	+	1518	WP_000003339.1	lysine--tRNA ligase	-
KTP13_RS03950 (819717)	819717..820262	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
KTP13_RS03955 (820527)	820527..821285	+	759	WP_000244318.1	amidase activator ActS	-
KTP13_RS03965 (821570)	821570..822376	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
KTP13_RS03970 (822651)	822651..822911	-	261	WP_023227725.1	hypothetical protein	-
KTP13_RS03975 (823079)	823079..823306	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
KTP13_RS03980 (823306)	823306..823704	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
KTP13_RS03985 (824508)	824508..825044	+	537	WP_023227726.1	STM3031 family outer membrane protein	-
KTP13_RS03990 (825091)	825091..825723	+	633	WP_023227727.1	YfdX family protein	-
KTP13_RS03995 (826442)	826442..827029	+	588	WP_023227728.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	821570..832897	11327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T207403 WP_000911337.1 NZ_CP077670:823306-823704 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T207403 NZ_CP102977:c2047012-2046650 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT207403 WP_000557545.1 NZ_CP077670:823079-823306 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT207403 NZ_CP102977:c2047179-2047009 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6