Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812192..812852 Replicon chromosome
Accession NZ_CP077670
Organism Salmonella enterica strain S90

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag KTP13_RS03915 Protein ID WP_000244755.1
Coordinates 812439..812852 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KTP13_RS03910 Protein ID WP_000351186.1
Coordinates 812192..812458 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP13_RS03890 (808501) 808501..808812 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KTP13_RS03895 (808976) 808976..809635 + 660 WP_000250289.1 hemolysin III family protein -
KTP13_RS03900 (809893) 809893..810879 + 987 WP_023226548.1 IS110 family transposase -
KTP13_RS03905 (810962) 810962..811942 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
KTP13_RS03910 (812192) 812192..812458 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KTP13_RS03915 (812439) 812439..812852 + 414 WP_000244755.1 protein YgfX Toxin
KTP13_RS03920 (812905) 812905..813426 - 522 WP_001055885.1 flavodoxin FldB -
KTP13_RS03925 (813539) 813539..814435 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KTP13_RS03930 (814459) 814459..815172 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KTP13_RS03935 (815178) 815178..816911 + 1734 WP_023227724.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T207402 WP_000244755.1 NZ_CP077670:812439-812852 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207402 NZ_CP102977:c1974630-1974379 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207402 WP_000351186.1 NZ_CP077670:812192-812458 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207402 NZ_CP102977:c1974389-1974216 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References