Detailed information of TA system TA207401

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 24352..24977
• Replicon: plasmid unnamed1
• Accession: NZ_CP077669
• Organism: Salmonella enterica strain SP

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KTP12_RS24710
• Protein ID: WP_080060985.1
• Coordinates: 24579..24977 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KTP12_RS24705
• Protein ID: WP_000450265.1
• Coordinates: 24352..24579 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP12_RS24705	24352..24579	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
KTP12_RS24710	24579..24977	+	399	WP_080060985.1	type II toxin-antitoxin system VapC family toxin	Toxin
KTP12_RS24715	24986..27256	-	2271	WP_023139332.1	type IV conjugative transfer system coupling protein TraD	-
KTP12_RS24720	27633..28364	-	732	WP_022743186.1	conjugal transfer complement resistance protein TraT	-
KTP12_RS24725	28400..28894	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	pefB / pefA / pefC / pefD / rck / spvB / spvC / fdeC	1..94048	94048

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14859.07 Da
• Isoelectric Point: 7.8604

>T207401 WP_080060985.1 NZ_CP077669:24579-24977 [Salmonella enterica]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSQGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T207401 NZ_CP102977:c1953258-1953124 [Staphylococcus aureus]
ATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCTAATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCT
TATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAATTAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT207401 WP_000450265.1 NZ_CP077669:24352-24579 [Salmonella enterica]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT207401 NZ_CP102977:1952993-1953134 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT