Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4436346..4437127 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag KTP12_RS21960 Protein ID WP_000626099.1
Coordinates 4436346..4436837 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KTP12_RS21965 Protein ID WP_001110452.1
Coordinates 4436834..4437127 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS21925 (4432341) 4432341..4432916 + 576 WP_001188509.1 transcriptional regulator -
KTP12_RS21935 (4433187) 4433187..4433264 - 78 Protein_4289 helix-turn-helix domain-containing protein -
KTP12_RS21940 (4433355) 4433355..4433687 - 333 WP_001165471.1 MerR family transcriptional regulator -
KTP12_RS21945 (4433759) 4433759..4434136 + 378 WP_000916345.1 EthD family reductase -
KTP12_RS21950 (4435169) 4435169..4435243 + 75 Protein_4292 porin family protein -
KTP12_RS21955 (4435346) 4435346..4436098 + 753 WP_000842434.1 non-specific acid phosphatase -
KTP12_RS21960 (4436346) 4436346..4436837 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
KTP12_RS21965 (4436834) 4436834..4437127 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KTP12_RS21970 (4437444) 4437444..4437665 + 222 WP_001576552.1 hypothetical protein -
KTP12_RS21975 (4437929) 4437929..4438804 + 876 WP_000921674.1 AraC family transcriptional regulator -
KTP12_RS21980 (4438801) 4438801..4439088 + 288 WP_001269916.1 transcriptional regulator RtsB -
KTP12_RS21985 (4439111) 4439111..4439326 + 216 WP_001595136.1 hypothetical protein -
KTP12_RS21990 (4439334) 4439334..4439603 + 270 WP_010989096.1 hypothetical protein -
KTP12_RS21995 (4439897) 4439897..4440802 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T207398 WP_000626099.1 NZ_CP077668:c4436837-4436346 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T207398 NZ_CP102975:c2476509-2476243 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATGCCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT207398 WP_001110452.1 NZ_CP077668:c4437127-4436834 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT207398 NZ_CP102975:c2476766-2476509 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACTACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References