Detailed information of TA system TA207398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4436346..4437127
• Replicon: chromosome
• Accession: NZ_CP077668
• Organism: Salmonella enterica strain SP

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: E8X9W8
• Locus tag: KTP12_RS21960
• Protein ID: WP_000626099.1
• Coordinates: 4436346..4436837 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: B5R979
• Locus tag: KTP12_RS21965
• Protein ID: WP_001110452.1
• Coordinates: 4436834..4437127 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP12_RS21925 (4432341)	4432341..4432916	+	576	WP_001188509.1	transcriptional regulator	-
KTP12_RS21935 (4433187)	4433187..4433264	-	78	Protein_4289	helix-turn-helix domain-containing protein	-
KTP12_RS21940 (4433355)	4433355..4433687	-	333	WP_001165471.1	MerR family transcriptional regulator	-
KTP12_RS21945 (4433759)	4433759..4434136	+	378	WP_000916345.1	EthD family reductase	-
KTP12_RS21950 (4435169)	4435169..4435243	+	75	Protein_4292	porin family protein	-
KTP12_RS21955 (4435346)	4435346..4436098	+	753	WP_000842434.1	non-specific acid phosphatase	-
KTP12_RS21960 (4436346)	4436346..4436837	-	492	WP_000626099.1	GNAT family N-acetyltransferase	Toxin
KTP12_RS21965 (4436834)	4436834..4437127	-	294	WP_001110452.1	DUF1778 domain-containing protein	Antitoxin
KTP12_RS21970 (4437444)	4437444..4437665	+	222	WP_001576552.1	hypothetical protein	-
KTP12_RS21975 (4437929)	4437929..4438804	+	876	WP_000921674.1	AraC family transcriptional regulator	-
KTP12_RS21980 (4438801)	4438801..4439088	+	288	WP_001269916.1	transcriptional regulator RtsB	-
KTP12_RS21985 (4439111)	4439111..4439326	+	216	WP_001595136.1	hypothetical protein	-
KTP12_RS21990 (4439334)	4439334..4439603	+	270	WP_010989096.1	hypothetical protein	-
KTP12_RS21995 (4439897)	4439897..4440802	-	906	WP_001268200.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (85-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17646.39 Da
• Isoelectric Point: 6.8437

>T207398 WP_000626099.1 NZ_CP077668:c4436837-4436346 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T207398 NZ_CP102975:c2476509-2476243 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATGCCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10977.61 Da
• Isoelectric Point: 8.6141

>AT207398 WP_001110452.1 NZ_CP077668:c4437127-4436834 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT207398 NZ_CP102975:c2476766-2476509 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACTACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• PDB: 7AK7

Antitoxin

• AlphaFold DB: A0A5I1DGA4