207397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4307720..4308236 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag KTP12_RS21295 Protein ID WP_000220578.1
Coordinates 4307720..4308004 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KTP12_RS21300 Protein ID WP_000212724.1
Coordinates 4307994..4308236 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS21280 (4302932) 4302932..4304584 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
KTP12_RS21285 (4304993) 4304993..4307131 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KTP12_RS21290 (4307252) 4307252..4307716 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KTP12_RS21295 (4307720) 4307720..4308004 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTP12_RS21300 (4307994) 4307994..4308236 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KTP12_RS21305 (4308314) 4308314..4310227 - 1914 WP_001212137.1 BglG family transcription antiterminator -
KTP12_RS21310 (4310244) 4310244..4310984 - 741 WP_000779263.1 KDGP aldolase family protein -
KTP12_RS21315 (4310981) 4310981..4312099 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KTP12_RS21320 (4312083) 4312083..4313216 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207397 WP_000220578.1 NZ_CP077668:c4308004-4307720 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207397 NZ_CP102975:c2422163-2421897 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAATAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCACATTGAAAGGTAGAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGACGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207397 WP_000212724.1 NZ_CP077668:c4308236-4307994 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207397 NZ_CP102975:c2422414-2422163 [Staphylococcus aureus]
ATGATTATTAAAACTTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAACAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAC
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References