207392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3574676..3575296 Replicon chromosome
Accession NZ_CP077668
Organism Salmonella enterica strain SP

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KTP12_RS17805 Protein ID WP_001280991.1
Coordinates 3575078..3575296 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KTP12_RS17800 Protein ID WP_000344807.1
Coordinates 3574676..3575050 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP12_RS17790 (3569815) 3569815..3571008 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KTP12_RS17795 (3571031) 3571031..3574180 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KTP12_RS17800 (3574676) 3574676..3575050 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KTP12_RS17805 (3575078) 3575078..3575296 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KTP12_RS17810 (3575475) 3575475..3576026 + 552 WP_001278792.1 maltose O-acetyltransferase -
KTP12_RS17815 (3576143) 3576143..3576613 + 471 WP_000136181.1 YlaC family protein -
KTP12_RS17820 (3576669) 3576669..3576809 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KTP12_RS17825 (3576815) 3576815..3577075 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KTP12_RS17830 (3577300) 3577300..3578850 + 1551 WP_000213139.1 EAL domain-containing protein -
KTP12_RS17840 (3579081) 3579081..3579470 + 390 WP_000961285.1 MGMT family protein -
KTP12_RS17845 (3579503) 3579503..3580072 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207392 WP_001280991.1 NZ_CP077668:3575078-3575296 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207392 NZ_CP102974:c2460373-2460107 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207392 WP_000344807.1 NZ_CP077668:3574676-3575050 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207392 NZ_CP102974:c2460630-2460373 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References