20739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2169138..2169652 Replicon chromosome
Accession NC_003923
Organism Staphylococcus aureus subsp. aureus MW2

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag MW_RS10955 Protein ID WP_000581793.1
Coordinates 2169138..2169347 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MW_RS10960 Protein ID WP_000138932.1
Coordinates 2169359..2169652 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW_RS10935 (MW2005) 2164647..2166005 - 1359 WP_000611483.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MW_RS10940 (MW2006) 2166020..2167090 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
MW_RS10945 (MW2007) 2167408..2168610 + 1203 WP_001109939.1 rod shape-determining protein RodA -
MW_RS10950 (MW2008) 2168873..2169010 - 138 WP_000828354.1 hypothetical protein -
MW_RS10955 (MW2009) 2169138..2169347 - 210 WP_000581793.1 heavy-metal-associated domain-containing protein Toxin
MW_RS10960 (MW2010) 2169359..2169652 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MW_RS10965 (MW2011) 2169818..2171302 + 1485 WP_000571549.1 cardiolipin synthase -
MW_RS10970 (MW2012) 2171330..2171977 + 648 WP_001187628.1 HD domain-containing protein -
MW_RS10980 (MW2013) 2172591..2173463 - 873 WP_000725802.1 membrane protein insertase YidC -
MW_RS10985 (MW2014) 2173549..2174190 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T20739 WP_000581793.1 NC_003923:c2169347-2169138 [Staphylococcus aureus subsp. aureus MW2]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T20739 NC_003923:c2169347-2169138 [Staphylococcus aureus subsp. aureus MW2]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTAATTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT20739 WP_000138932.1 NC_003923:c2169652-2169359 [Staphylococcus aureus subsp. aureus MW2]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT20739 NC_003923:c2169652-2169359 [Staphylococcus aureus subsp. aureus MW2]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCGATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References