Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2756..3348 Replicon plasmid unnamed1
Accession NZ_CP077663
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag KTP10_RS23345 Protein ID WP_000520549.1
Coordinates 2756..3004 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag KTP10_RS23350 Protein ID WP_000681613.1
Coordinates 3001..3348 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS23320 253..795 + 543 WP_001083906.1 hypothetical protein -
KTP10_RS23325 792..1043 + 252 WP_001230707.1 hypothetical protein -
KTP10_RS23330 1030..1257 + 228 WP_000801440.1 hypothetical protein -
KTP10_RS23335 1711..2010 + 300 WP_000650309.1 hypothetical protein -
KTP10_RS23340 2101..2451 + 351 WP_159124558.1 hypothetical protein -
KTP10_RS23345 2756..3004 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
KTP10_RS23350 3001..3348 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KTP10_RS23355 3709..4212 + 504 WP_000781813.1 relaxosome-coupling protein TaxA -
KTP10_RS23360 4216..5445 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
KTP10_RS23365 5522..5815 + 294 WP_060598542.1 sigma factor-like helix-turn-helix DNA-binding protein -
KTP10_RS23370 5812..6027 + 216 WP_000760375.1 EexN family lipoprotein -
KTP10_RS23375 6383..7003 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
KTP10_RS23380 7017..7343 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33308 33308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T207376 WP_000520549.1 NZ_CP077663:2756-3004 [Salmonella enterica]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T207376 NZ_CP102971:c1893521-1893369 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT207376 WP_000681613.1 NZ_CP077663:3001-3348 [Salmonella enterica]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT207376 NZ_CP102971:c1894145-1893546 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References