Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 792..1257 Replicon plasmid unnamed1
Accession NZ_CP077663
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag KTP10_RS23325 Protein ID WP_001230707.1
Coordinates 792..1043 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag KTP10_RS23330 Protein ID WP_000801440.1
Coordinates 1030..1257 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS23320 253..795 + 543 WP_001083906.1 hypothetical protein -
KTP10_RS23325 792..1043 + 252 WP_001230707.1 hypothetical protein Toxin
KTP10_RS23330 1030..1257 + 228 WP_000801440.1 hypothetical protein Antitoxin
KTP10_RS23335 1711..2010 + 300 WP_000650309.1 hypothetical protein -
KTP10_RS23340 2101..2451 + 351 WP_159124558.1 hypothetical protein -
KTP10_RS23345 2756..3004 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
KTP10_RS23350 3001..3348 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
KTP10_RS23355 3709..4212 + 504 WP_000781813.1 relaxosome-coupling protein TaxA -
KTP10_RS23360 4216..5445 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
KTP10_RS23365 5522..5815 + 294 WP_060598542.1 sigma factor-like helix-turn-helix DNA-binding protein -
KTP10_RS23370 5812..6027 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33308 33308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T207375 WP_001230707.1 NZ_CP077663:792-1043 [Salmonella enterica]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T207375 NZ_CP102971:c814642-814454 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT207375 WP_000801440.1 NZ_CP077663:1030-1257 [Salmonella enterica]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT207375 NZ_CP102971:c814931-814671 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References