Detailed information of TA system TA207372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4335772..4336553
• Replicon: chromosome
• Accession: NZ_CP077662
• Organism: Salmonella enterica strain S146

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A3Y7QYP9
• Locus tag: KTP10_RS21010
• Protein ID: WP_023231674.1
• Coordinates: 4335772..4336263 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3Y7QYQ5
• Locus tag: KTP10_RS21015
• Protein ID: WP_023231675.1
• Coordinates: 4336260..4336553 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP10_RS20990 (4332652)	4332652..4333482	-	831	WP_023231671.1	fimbria/pilus periplasmic chaperone	-
KTP10_RS20995 (4333684)	4333684..4333989	-	306	WP_000370555.1	PapB/FocB family fimbrial expression transcriptional regulator	-
KTP10_RS23550 (4334522)	4334522..4334665	+	144	Protein_4105	transposase	-
KTP10_RS21000 (4334682)	4334682..4335028	+	347	Protein_4106	Rpn family recombination-promoting nuclease/putative transposase	-
KTP10_RS21005 (4335309)	4335309..4335557	-	249	Protein_4107	IS481 family transposase	-
KTP10_RS21010 (4335772)	4335772..4336263	-	492	WP_023231674.1	GNAT family N-acetyltransferase	Toxin
KTP10_RS21015 (4336260)	4336260..4336553	-	294	WP_023231675.1	DUF1778 domain-containing protein	Antitoxin
KTP10_RS21020 (4336871)	4336871..4337093	+	223	Protein_4110	hypothetical protein	-
KTP10_RS21025 (4337359)	4337359..4338234	+	876	WP_023195838.1	AraC family transcriptional regulator	-
KTP10_RS21030 (4338231)	4338231..4338518	+	288	WP_001269916.1	transcriptional regulator RtsB	-
KTP10_RS21035 (4338511)	4338511..4338693	-	183	WP_023231676.1	ATP-binding cassette domain-containing protein	-
KTP10_RS21040 (4338713)	4338713..4338812	+	100	Protein_4114	hypothetical protein	-
KTP10_RS21045 (4338920)	4338920..4339054	+	135	Protein_4115	hypothetical protein	-
KTP10_RS21050 (4339349)	4339349..4340254	-	906	WP_023231677.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17643.45 Da
• Isoelectric Point: 7.2655

>T207372 WP_023231674.1 NZ_CP077662:c4336263-4335772 [Salmonella enterica]
MISPPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQATGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T207372 NZ_CP102970:c2074482-2074273 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10930.60 Da
• Isoelectric Point: 9.8590

>AT207372 WP_023231675.1 NZ_CP077662:c4336553-4336260 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPVPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT207372 NZ_CP102970:c2074787-2074494 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACACAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• AlphaFold DB: A0A3Y7QYP9

Antitoxin

• AlphaFold DB: A0A3Y7QYQ5