207371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4185199..4185842 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag KTP10_RS20220 Protein ID WP_000048134.1
Coordinates 4185426..4185842 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag KTP10_RS20215 Protein ID WP_001261294.1
Coordinates 4185199..4185429 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS20200 (4180248) 4180248..4181900 + 1653 WP_023232256.1 alpha,alpha-phosphotrehalase -
KTP10_RS20205 (4182309) 4182309..4184447 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KTP10_RS20210 (4184568) 4184568..4185032 + 465 WP_023232257.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KTP10_RS20215 (4185199) 4185199..4185429 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KTP10_RS20220 (4185426) 4185426..4185842 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
KTP10_RS20225 (4185903) 4185903..4187816 - 1914 WP_023232258.1 BglG family transcription antiterminator -
KTP10_RS20230 (4187833) 4187833..4188573 - 741 WP_023229489.1 KDGP aldolase family protein -
KTP10_RS20235 (4188570) 4188570..4189688 - 1119 WP_023232259.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KTP10_RS20240 (4189672) 4189672..4190805 - 1134 WP_023232260.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T207371 WP_000048134.1 NZ_CP077662:4185426-4185842 [Salmonella enterica]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T207371 NZ_CP102970:c2054894-2054532 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT207371 WP_001261294.1 NZ_CP077662:4185199-4185429 [Salmonella enterica]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT207371 NZ_CP102970:c2055061-2054891 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References