Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4143161..4143711 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag KTP10_RS19990 Protein ID WP_001199743.1
Coordinates 4143161..4143469 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag KTP10_RS19995 Protein ID WP_000016244.1
Coordinates 4143472..4143711 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS19975 (4141185) 4141185..4141964 - 780 WP_023232244.1 HNH endonuclease -
KTP10_RS19980 (4142125) 4142125..4142439 + 315 WP_023232245.1 hypothetical protein -
KTP10_RS19985 (4142419) 4142419..4142726 - 308 Protein_3909 Arm DNA-binding domain-containing protein -
KTP10_RS19990 (4143161) 4143161..4143469 - 309 WP_001199743.1 CcdB family protein Toxin
KTP10_RS19995 (4143472) 4143472..4143711 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KTP10_RS20000 (4143824) 4143824..4144072 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
KTP10_RS20005 (4144149) 4144149..4144457 - 309 Protein_3913 DUF4942 domain-containing protein -
KTP10_RS20010 (4144477) 4144477..4145454 - 978 WP_223156438.1 IS630 family transposase -
KTP10_RS20025 (4146212) 4146212..4147231 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
KTP10_RS20030 (4147259) 4147259..4147789 - 531 WP_023232248.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4144477..4145409 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T207370 WP_001199743.1 NZ_CP077662:c4143469-4143161 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T207370 NZ_CP102970:c1902467-1902315 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT207370 WP_000016244.1 NZ_CP077662:c4143711-4143472 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT207370 NZ_CP102970:c1903091-1902492 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAGGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References