Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3452942..3453562 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KTP10_RS16705 Protein ID WP_001280991.1
Coordinates 3453344..3453562 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A4Q7HJ94
Locus tag KTP10_RS16700 Protein ID WP_023231707.1
Coordinates 3452942..3453316 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS16690 (3448081) 3448081..3449274 + 1194 WP_023231706.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KTP10_RS16695 (3449297) 3449297..3452446 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KTP10_RS16700 (3452942) 3452942..3453316 + 375 WP_023231707.1 Hha toxicity modulator TomB Antitoxin
KTP10_RS16705 (3453344) 3453344..3453562 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KTP10_RS16710 (3453741) 3453741..3454292 + 552 WP_001278793.1 maltose O-acetyltransferase -
KTP10_RS16715 (3454410) 3454410..3454880 + 471 WP_000136183.1 YlaC family protein -
KTP10_RS16720 (3454936) 3454936..3455076 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KTP10_RS16725 (3455082) 3455082..3455342 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KTP10_RS16730 (3455567) 3455567..3457117 + 1551 WP_023231708.1 EAL domain-containing protein -
KTP10_RS16740 (3457348) 3457348..3457737 + 390 WP_000961285.1 MGMT family protein -
KTP10_RS16745 (3457770) 3457770..3458339 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207366 WP_001280991.1 NZ_CP077662:3453344-3453562 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207366 NZ_CP102968:c2045986-2045777 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1444

>AT207366 WP_023231707.1 NZ_CP077662:3452942-3453316 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207366 NZ_CP102968:c2046291-2045998 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACACAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q7HJ94

References