207357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2384975..2385497 Replicon chromosome
Accession NZ_CP077662
Organism Salmonella enterica strain S146

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag KTP10_RS11535 Protein ID WP_000221343.1
Coordinates 2384975..2385259 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KTP10_RS11540 Protein ID WP_000885424.1
Coordinates 2385249..2385497 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTP10_RS11515 (2381050) 2381050..2382558 - 1509 WP_048348841.1 FAD-dependent oxidoreductase -
KTP10_RS11520 (2382603) 2382603..2383091 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
KTP10_RS11525 (2383284) 2383284..2384363 + 1080 WP_023231841.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KTP10_RS11530 (2384415) 2384415..2384804 - 390 WP_023206403.1 RidA family protein -
KTP10_RS11535 (2384975) 2384975..2385259 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTP10_RS11540 (2385249) 2385249..2385497 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTP10_RS11545 (2386172) 2386172..2386594 + 423 WP_048348840.1 PTS sugar transporter subunit IIA -
KTP10_RS11550 (2386654) 2386654..2386935 + 282 WP_023218025.1 PTS sugar transporter subunit IIB -
KTP10_RS11555 (2386947) 2386947..2388338 + 1392 WP_023218026.1 PTS galactitol transporter subunit IIC -
KTP10_RS11560 (2388416) 2388416..2389927 + 1512 WP_023231843.1 FGGY family carbohydrate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2379613..2400262 20649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T207357 WP_000221343.1 NZ_CP077662:c2385259-2384975 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T207357 NZ_CP102967:c821054-820866 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCATAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT207357 WP_000885424.1 NZ_CP077662:c2385497-2385249 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT207357 NZ_CP102967:c821343-821083 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References