Detailed information of TA system TA207356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1080288..1081102
• Replicon: chromosome
• Accession: NZ_CP077662
• Organism: Salmonella enterica strain S146

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: KTP10_RS05200
• Protein ID: WP_137119288.1
• Coordinates: 1080288..1080815 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: KTP10_RS05205
• Protein ID: WP_000855694.1
• Coordinates: 1080812..1081102 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTP10_RS05180 (1075500)	1075500..1078067	-	2568	WP_129339431.1	DNA mismatch repair protein MutS	-
KTP10_RS05185 (1078226)	1078226..1078752	+	527	Protein_1015	cytoplasmic protein	-
KTP10_RS05190 (1078995)	1078995..1079651	-	657	WP_000420451.1	protein-serine/threonine phosphatase	-
KTP10_RS05195 (1079992)	1079992..1080215	+	224	Protein_1017	IS5/IS1182 family transposase	-
KTP10_RS05200 (1080288)	1080288..1080815	-	528	WP_137119288.1	GNAT family N-acetyltransferase	Toxin
KTP10_RS05205 (1080812)	1080812..1081102	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
KTP10_RS05210 (1081372)	1081372..1081561	-	190	Protein_1020	IS3 family transposase	-
KTP10_RS05215 (1081966)	1081966..1082409	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
KTP10_RS05220 (1082866)	1082866..1083516	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-
KTP10_RS05225 (1083513)	1083513..1085201	+	1689	WP_000848114.1	type III secretion system outer membrane ring protein InvG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1080075..1088829	8754
	-	flank	IS/Tn	-	-	1080075..1080215	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19108.94 Da
• Isoelectric Point: 9.6421

>T207356 WP_137119288.1 NZ_CP077662:c1080815-1080288 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYTQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDHPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T207356 NZ_CP102966:c2476133-2475867 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATACTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT207356 WP_000855694.1 NZ_CP077662:c1081102-1080812 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT207356 NZ_CP102966:c2476390-2476133 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAGGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7