Detailed information of TA system TA207353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 4514963..4516746
• Replicon: chromosome
• Accession: NZ_CP077661
• Organism: Enterobacter cloacae complex sp. ECL112

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KQQ05_RS21875
• Protein ID: WP_032609694.1
• Coordinates: 4514963..4516312 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: KQQ05_RS21880
• Protein ID: WP_003859317.1
• Coordinates: 4516309..4516746 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQQ05_RS21850	4510786..4511721	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
KQQ05_RS21855	4511890..4512285	+	396	WP_217304916.1	CidA/LrgA family protein	-
KQQ05_RS21860	4512282..4512977	+	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
KQQ05_RS21865	4513106..4513990	+	885	WP_032609693.1	cytidine deaminase	-
KQQ05_RS21870	4514118..4514828	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
KQQ05_RS21875	4514963..4516312	+	1350	WP_032609694.1	HipA domain-containing protein	Toxin
KQQ05_RS21880	4516309..4516746	+	438	WP_003859317.1	helix-turn-helix transcriptional regulator	Antitoxin
KQQ05_RS21885	4516785..4517795	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
KQQ05_RS21890	4517811..4519331	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
KQQ05_RS21895	4519411..4520409	-	999	WP_003859322.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
KQQ05_RS21900	4520705..4521727	-	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51149.84 Da
• Isoelectric Point: 4.6562

>T207353 WP_032609694.1 NZ_CP077661:4514963-4516312 [Enterobacter cloacae complex sp. ECL112]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T207353 NZ_CP102966:c2065056-2064694 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT207353 WP_003859317.1 NZ_CP077661:4516309-4516746 [Enterobacter cloacae complex sp. ECL112]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT207353 NZ_CP102966:c2065223-2065053 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9