Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3785502..3786241 Replicon chromosome
Accession NZ_CP077661
Organism Enterobacter cloacae complex sp. ECL112

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag KQQ05_RS18400 Protein ID WP_032609220.1
Coordinates 3785502..3785987 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag KQQ05_RS18405 Protein ID WP_003857131.1
Coordinates 3785975..3786241 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ05_RS18385 3782370..3783803 - 1434 WP_042863492.1 restriction endonuclease -
KQQ05_RS18390 3783824..3784627 - 804 WP_000619352.1 TIGR02391 family protein -
KQQ05_RS18395 3784649..3785128 - 480 WP_001542736.1 hypothetical protein -
KQQ05_RS18400 3785502..3785987 - 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
KQQ05_RS18405 3785975..3786241 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
KQQ05_RS18410 3786305..3787234 - 930 WP_032609221.1 LysR family transcriptional regulator -
KQQ05_RS18415 3787364..3788752 + 1389 WP_032609222.1 MFS transporter -
KQQ05_RS18420 3788774..3789769 - 996 WP_042863494.1 DUF2891 domain-containing protein -
KQQ05_RS18425 3789779..3790765 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3764488..3786241 21753


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T207344 WP_032609220.1 NZ_CP077661:c3785987-3785502 [Enterobacter cloacae complex sp. ECL112]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T207344 NZ_CP102962:c2488110-2487844 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT207344 WP_003857131.1 NZ_CP077661:c3786241-3785975 [Enterobacter cloacae complex sp. ECL112]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT207344 NZ_CP102962:c2488361-2488110 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCTATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References