Detailed information of TA system TA207341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1539498..1540105
• Replicon: chromosome
• Accession: NZ_CP077661
• Organism: Enterobacter cloacae complex sp. ECL112

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: KQQ05_RS07460
• Protein ID: WP_057979982.1
• Coordinates: 1539498..1539683 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KQQ05_RS07465
• Protein ID: WP_023315016.1
• Coordinates: 1539698..1540105 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQQ05_RS07445	1534817..1536655	+	1839	WP_023323871.1	selenocysteine-specific translation elongation factor	-
KQQ05_RS07450	1536659..1537543	-	885	WP_003860164.1	ROK family protein	-
KQQ05_RS07455	1537710..1539248	+	1539	WP_006808612.1	aldehyde dehydrogenase AldB	-
KQQ05_RS07460	1539498..1539683	+	186	WP_057979982.1	type II toxin-antitoxin system HicA family toxin	Toxin
KQQ05_RS07465	1539698..1540105	+	408	WP_023315016.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KQQ05_RS07470	1540109..1541185	-	1077	WP_023323870.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
KQQ05_RS07475	1541646..1542101	+	456	WP_023323869.1	4Fe-4S dicluster domain-containing protein	-
KQQ05_RS07480	1542109..1543362	-	1254	WP_015572749.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T207341 WP_057979982.1 NZ_CP077661:1539498-1539683 [Enterobacter cloacae complex sp. ECL112]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T207341 NZ_CP102962:c1981622-1981470 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAGGACAGTCAGTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT207341 WP_023315016.1 NZ_CP077661:1539698-1540105 [Enterobacter cloacae complex sp. ECL112]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT207341 NZ_CP102962:c1982246-1981647 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCTGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0