Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 464661..465318 Replicon chromosome
Accession NZ_CP077661
Organism Enterobacter cloacae complex sp. ECL112

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag KQQ05_RS02255 Protein ID WP_022649305.1
Coordinates 464661..465071 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag KQQ05_RS02260 Protein ID WP_003863437.1
Coordinates 465052..465318 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQQ05_RS02235 460659..462392 - 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -
KQQ05_RS02240 462398..463111 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KQQ05_RS02245 463140..464036 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
KQQ05_RS02250 464138..464659 + 522 WP_003863440.1 flavodoxin FldB -
KQQ05_RS02255 464661..465071 - 411 WP_022649305.1 protein YgfX Toxin
KQQ05_RS02260 465052..465318 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
KQQ05_RS02265 465613..466593 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
KQQ05_RS02270 466679..467338 - 660 WP_003863433.1 hemolysin III family protein -
KQQ05_RS02275 467605..468336 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
KQQ05_RS02280 468453..469886 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T207339 WP_022649305.1 NZ_CP077661:c465071-464661 [Enterobacter cloacae complex sp. ECL112]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T207339 NZ_CP102961:c2516422-2516156 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT207339 WP_003863437.1 NZ_CP077661:c465318-465052 [Enterobacter cloacae complex sp. ECL112]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT207339 NZ_CP102961:c2516679-2516422 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References